胃癌与淋巴结转移组织Mina53和PCNA的表达临床意义分析

目的：观察Mina53和PCNA在胃癌组织及淋巴结转移灶中的表达情况，分析二者与临床病理指标之间的关系，探讨其在胃癌发生、发展中的作用及临床意义。方法采用免疫组化方法检测59例患者胃癌组织及淋巴结转移灶中 Mina53、PCNA的表达情况，并分析二者表达与临床病理特征的关系。结果胃癌组织和淋巴结转移灶中Mina53表达率分别为79.7%和96.2%，明显高于正常胃黏膜组织的表达（P＜0.05）。Mina53在有淋巴结转移组和无淋巴结转移组的胃癌组织中的阳性表达率分别为69.7%和75.8%。Mina53和PCNA表达在患者性别、年龄和肿瘤部位之间无显著性差异（P＞0.05），与TNM分期和分化程度有关，P＜0.05。与 PCNA 表达存在正相关（r＝0.598，P＝0.000）。结论 Mina53和 PCNA 与胃癌的TNM分期、分化程度等临床病理特征相关。对判断胃癌的浸润能力、淋巴结转移及预后方面有指导意义。

Expression and prognostic value of Mina53 and PCNA in samples from gastric carcinomas and lymph-node metastases

Objective To observe the expression of Mina53 and PCNA in gastric cancer and lymph node metastasis, to analysis the relationship between their and the clinical pathological indicators and to investigate the role and clinical significance in gastric cancer origination and development. Methods The expressions of Mina53 and PCNA in 59 gastric cancer and lymph node metastasis patients were determined by immunohistochemistry. The relationship between the express of both and clinicopathological characteristics were analysis. Results The expression rate of Mina53 in gastric cancer tissues and lymph node metastasis were 79.7% and 96.2%, the expression of their were significantly higher than the normal gastric mucosa （P＆lt;0.05）. The positive expression rate of Mina53 in gastric cancer tissue of the group with lymph node metastasis and the group without lymph node metastasis were 69.7% and 75.8%. There are no significant difference between the expression of Mina53 and PCNA and the gender, age, tumor site of patients （P＆gt;0.05）, the expression of Mina53 and PCNA are related to TNM stage and degree of differentiation（P＆lt;0.05）, they are positively correlated with PCNA expression（r=0.598, P=0.000）. Conclusions Mina53 and PCNA are related to the TNM stage, the degree of differentiation and the clinicopathological characteristics. It has a guiding significance in aspects of judgmenting the infiltration capacity of gastric cancer, lymph node metastasis and the prognosis.