| 丹参酮微乳制剂的HPLC指纹图谱研究 |
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| 引用本文： | 吕慧怡,范青,张宁,李波阳.丹参酮微乳制剂的HPLC指纹图谱研究[J].中国中药杂志,2004,29(11):1047-1049. |
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| 作者姓名： | 吕慧怡 范青 张宁 李波阳 |
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| 作者单位： | 1. 大连医科大学,附属二院,药剂科,辽宁,大连,116027
2. 大连美罗股份新特药公司,辽宁,大连,116011 |
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| 摘 要： | 目的 :建立丹参酮微乳的HPLC指纹图谱。方法 :采用HPLC ,HypersilC18色谱柱 (4.6mm× 250mm ,5μm) ;流动相 0.5%磷酸溶液 (A)、乙腈 (B)和梯度洗脱 ,B的体积分数在 60min内由 10 %线性增长到 80 % ;检测波长270nm ;分析时间 60min ;流速 1.0mL·min-1。结果 :标示出丹参酮微乳制剂 7个共有峰。结论 :本方法建立的丹参酮微乳HPLC指纹图谱方法简便、可靠、专属性强 ,为丹参酮微乳质量标准的制定提供了理论依据。
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| 关 键 词： | 丹参酮微乳 丹参酮 高效液相色谱法 指纹图谱 |
| 文章编号： | 1001-5302(2004)11-1047-03 |
| 收稿时间： | 2004/6/15 0:00:00 |
Studies on HPLC fingerprints of tanshinone microemulsion |
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| Studies on HPLC fingerprints of tanshinone microemulsion.Studies on HPLC fingerprints of tanshinone microemulsion[J].China Journal of Chinese Materia Medica,2004,29(11):1047-1049. |
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| Authors: | Studies on HPLC fingerprints of tanshinone microemulsion |
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| Institution: | Department of Pharmacy, Second Affiliated Hospital of Dalian Medical University, Dalian 116027, China. |
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| Abstract: | OBJECTIVE: To establish the HPLC fingerprints of tanshinone microemulsion. METHOD: HPLC analysis was carried on Hypersil C18(4.6 mm x 250 mm, 5 microm) analytical column; the acetonitrile and 0.5% phosphoric acid solution were used as mobile phases with gradient elution at a flow rate of 1.0 mL x min(-1). The UV detection wavelength was set at 270 nm. RESULT: Six peaks on HPLC fingerprint of Tanshinone Microemulsion are indexed. CONCLUSION: The method developed in the present study is convenient, reliable, and can be used as a quality control method for Tanshinone Microemulsion. |
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| Keywords: | tanshinone microemulsion tanshinone HPLC fi ngerprints |
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