| 羟丙基-β-环糊精对氯硝西泮包合作用的研究 |
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| 引用本文： | 李瑞,徐群为,许荔新,张静. 羟丙基-β-环糊精对氯硝西泮包合作用的研究[J]. 中国药房, 2006, 17(15): 1137-1139 |
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| 作者姓名： | 李瑞 徐群为 许荔新 张静 |
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| 作者单位： | 1. 南京医科大学药学院,南京市,210029
2. 白求恩医科大学制药厂,长春市,130012 |
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| 摘 要： | 目的:研究羟丙基-β-环糊精(HP-β-CD)在水溶液中对氯硝西泮的包合作用。方法:采用相溶解度法、等摩尔系列法、紫外吸收光谱法等方法考察氯硝西泮与HP-β-CD在水溶液中包合作用、包合比及包合过程中的热力学参数变化。结果:在不同温度(25℃、35℃、45℃)的蒸馏水及不同pH(4·0、6·0、7·0)的缓冲液中,氯硝西泮的溶解度均随HP-β-CD溶液浓度的增加而呈线性增加,相溶解度图为AL型。结论:在本研究条件下,氯硝西泮与HP-β-CD可自发地形成摩尔比1∶1的包合物。
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| 关 键 词： | 氯硝西泮 HP-β-CD 溶解度 包合物 |
| 文章编号： | 1001-0408(2006)15-1137-03 |
| 收稿时间： | 2005-11-08 |
| 修稿时间： | 2006-01-16 |
Complexation of Clonazepam with Hydroxypropyl-β-cyclodextrin |
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| LI Rui,XU Qunwei,XU Lixin,ZHANG Jing. Complexation of Clonazepam with Hydroxypropyl-β-cyclodextrin[J]. China Pharmacy, 2006, 17(15): 1137-1139 |
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| Authors: | LI Rui XU Qunwei XU Lixin ZHANG Jing |
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| Affiliation: | 1,School of Pharmacy, Nanjing Medical University, Nanjing 210029,China;2,Pharmaceuticals Company of Norman Bethhune University of Medical Sciences, Changchun 130012, China |
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| Abstract: | OBJECTIVE:To investigate the complexation of clonazepam with hydroxypropyl-β-cyclodextrin(HP-β-CD)in aqueous solutions.METHODS:The complexation of clonazepam with(HP-β-CD),the inclusion molar ratio of host and guest molecules and thermodynamic parameters were detected using phase solubility method,equimolar series method,UV absorption spectroscopy etc.RESULTS:The solubility of clonazepam increased linearly with the increase of(HP-β-CD)level in aqueous solutions at different temperatures(25℃,35℃and45℃)and in buffers at different pH values(4.0,6.0and7.0),the phase solubility diagram was classified as type AL.CONCLUSIONS:Under the above research condition,the incl_ usion complexes of clonazepam with(HP-β-CD)can be formed spontaneously at a molar ratio of1∶1. |
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| Keywords: | Clonazepam Hydroxypropyl-β-cyclodextrin Solubility Inclusion complex |
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