| 大肠肿瘤组织中EB病毒的原位杂交检测 |
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| 引用本文： | 刘换新,丁彦青,孙亚欧,梁力,杨玉芳,齐宗利,刘继红,熊萍霞. 大肠肿瘤组织中EB病毒的原位杂交检测[J]. 南方医科大学学报, 2002, 22(10): 915-917 |
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| 作者姓名： | 刘换新 丁彦青 孙亚欧 梁力 杨玉芳 齐宗利 刘继红 熊萍霞 |
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| 作者单位： | 1. 第一军医大学病理教研室,广东广州,510515
2. 二炮北京苏州街干休所卫生所,北京,100075 |
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| 基金项目： | 广东省科技攻关项目(C30903) |
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| 摘 要： | 目的探讨EB病毒感染与人大肠癌发生的关系。方法用原位分子杂交法对130例人大肠癌标本中EB病毒小分子RNA片段进行检测。结果130例标本中有6例(4.48%)癌组织呈阳性反应,其中4例为男性,4例有明显淋巴细胞浸润。结论EB病毒感染可能与我国部分大肠腺癌的发生有关,肿瘤细胞间质中大量淋巴细胞浸润可能是EB病毒感染的重要病理学特征。
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| 关 键 词： | 结肠直肠肿瘤 疱疹病毒4型 人 原位杂交 |
| 文章编号： | 1000-2588(2002)10-0915-03 |
| 修稿时间： | 2002-05-30 |
Detection of Epstein-Barr virus in human colorectal cancer by in situ hybridazition |
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| LIU Huan-xin ,DING Yan-qing ,SUN Ya-ou ,LIANG Li ,YANG Yu-fang ,QI Zong-li ,LIU Ji-hong ,XIONG Ping-xia. Detection of Epstein-Barr virus in human colorectal cancer by in situ hybridazition[J]. Journal of Southern Medical University, 2002, 22(10): 915-917 |
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| Authors: | LIU Huan-xin DING Yan-qing SUN Ya-ou LIANG Li YANG Yu-fang QI Zong-li LIU Ji-hong XIONG Ping-xia |
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| Affiliation: | LIU Huan-xin 1,DING Yan-qing 1,SUN Ya-ou 2,LIANG Li 1,YANG Yu-fang 1,QI Zong-li 1,LIU Ji-hong 1,XIONG Ping-xia 11 Department of Pathology,First Military Medical University,Guangzhou 510515 |
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| Abstract: | Objective To investigate the relationship between Epstein-Barr virus (EBV) and the pathogenesis of human colorectal cancer. Methods The small-molecule RNA fragments of EBV was examined by in situ hybridization in colorectal cancer specimens obtained from 130 patients. Results EBV was found in the 6 of 130 colorectal cancer cases. EBV positivity was more prevalent in male patients (4/6), and the tumor tissues of the 4 EBV-positive cases were featured by obvious stromal infiltration by the lymphocytes (4/6). Conclusion EBV infection might be related to the pathogenesis of some colorectal adenocarcinomas in China, and intensive lymphocyte infiltration in the stroma of the tumor tissues can be an important pathological indication of EBV infection in colorectal tumors. |
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| Keywords: | colorectal neoplasms herpesvirus 4 human in situ hybridization |
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