湖北安陆市肺结核人群的戊肝血清流行病学特征分析

目的了解肺结核人群中的戊型肝炎(戊肝)流行特征,为更有效地开展肺结核和戊肝防治工作提供科学依据。方法采集2015年10月至2016年9月采集湖北省安陆市173人肺结核患者的血清,进行肝功能、抗-HEV IgG和抗-HEV IgM检测,对抗-HEV IgM阳性样本进行HEV RNA检测,同时收集其人口学资料和其他疾病感染史。结果共调查173例肺结核人群,肺结核人群抗-HEV IgM阳性率为0.58%(1/173),肺结核人群抗-HEV IgG阳性率为38.73%(67/173),HEV RNA未检出。肺结核患者中抗-HEV IgG阳性率与年龄呈线性关系,随年龄增加而增加。肺结核患者有肝功能异常史的戊肝既往感染率较高。肺结核患者中抗-HEV IgG阳性率在性别、肺结核病程长短、区域、职业上分布差异均无统计学意义(P0.05)。结论活动期的肺结核人群HEV感染不容忽视,积极开展两病双向筛查的同时需采取针对性的预防和治疗措施。

Analysis of Hepatitis E serum epidemiology among tuberculosis population in Anlu City,Hubei Province

Objective To analyze hepatitis E serum epidemiology in tuberculosis population and provide scientific basis for the control of tuberculosis and HEV.Methods 173 serum samples were collected from October 2015 to September 2016 in Aulu.Anti-HEV IgM positive samples were tested by HEV RNA.Liver function screening,demographic data andother diseases history were collected from 173 TB patients.Results Anti-HEV IgM positive rate was 0.58％ (1/173),and Anti-HEV IgG positive rate was 38.73％ (67/173).No HEV RNA was detected.Anti-HEV IgG positive rate had a linear relationship with age,and increased with age.A higher HEV infection rate was found among the patients with the history of abnormal liver function.Anti-HEV IgG positive rates among pulmonary TB patients had no statistical differences with the following factors:such as gender,length of the course of TB,distribution of regions and occupations.Conclusion HEV infection of active pulmonary TB should not be ignored,actively carrying out two-way screening for the two diseases,and taking targeted prevention and treatment measures were needed.