| 阿昔洛韦白蛋白微球的制备及体外释药 |
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| 引用本文： | 杨秀岭,张志清,董立. 阿昔洛韦白蛋白微球的制备及体外释药[J]. 中国药学杂志, 2000, 35(10): 676-678 |
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| 作者姓名： | 杨秀岭 张志清 董立 |
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| 作者单位： | 河北医科大学第二医院药剂科!河北石家庄市050000(杨秀岭，张志清，李素民，樊德厚)，河北医科大学药学院!94级实习生(董立) |
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| 摘 要： | 目的 优化阿昔洛韦白蛋白微球的制备工艺，并对其形态学性质、载药量、体外释药进行考察。方法 用乳化热固化法制备微球，用动态透析法进行体外释药。结果 微球平均粒径为(0.94±0.15)μm，载药量为(16.07±1.04)%，体外释药方程1-Q=0.815 e-0.66402t+0.1625e-0.01657tt1/2α=1.044 h，t1/2β=41.82 h。结论 微球外观圆整、均匀，体外释药符合长效制剂的特征。
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| 关 键 词： | 阿昔洛韦 白蛋白 微球 |
| 收稿时间： | 1998-09-18; |
| 修稿时间： | 1998-09-18 |
Studies on the preparation and in vitro release of aciclovir-loaded albumin microspheres |
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| YANG Xiu ling,ZHANG Zhi qing,Dong Li,LI Su min,FAN De hou. Studies on the preparation and in vitro release of aciclovir-loaded albumin microspheres[J]. Chinese Pharmaceutical Journal, 2000, 35(10): 676-678 |
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| Authors: | YANG Xiu ling ZHANG Zhi qing Dong Li LI Su min FAN De hou |
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| Affiliation: | Department of Pharmacy,The Second Affiliated Hospital of Hebei Medical University,Shijiazhuang 050000,China |
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| Abstract: | OBJECTIVE To study the preparation of aciclovir-loaded albumin microspheres (ACV-BSA-MS) and evaluate its morphology,drug loading and release in vitro. METHODS The ACV-BSA-MS was prepared by emulsion-heat stabilization techniques. RESULTS The mean diameter of ACV-BSA-MS prepared under optimum conditions was (0.94±0.15) μm.The drug loading was (16.07±1.04)%.The in vitro release equation was 1-Q=0.8151e-0.66402t+0.1625e-0.01657t,t1/2α=1.044 h,t1/2β=41.82 h. CONCLUSION The ACV-BSA-MS prepared under optimum conditions had regular morphology with a high drug loading and in vitro release properties confirmed to that of long-acting preparations. |
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| Keywords: | aciclovir albumin microspheres |
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