| 蝮蛇抗栓酶治疗心血管疾病40例 |
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| 引用本文： | 杨菊贤,侯仁骏,徐济民,黄震华,冯士民,汪敏.蝮蛇抗栓酶治疗心血管疾病40例[J].中国新药与临床杂志,1990(1). |
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| 作者姓名： | 杨菊贤 侯仁骏 徐济民 黄震华 冯士民 汪敏 |
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| 作者单位： | 上海第二医科大学附属第九人民医院 上海200012
(杨菊贤，侯仁骏，徐济民，黄震华，冯士民)，上海第二医科大学附属第九人民医院 上海200012(汪敏) |
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| 摘 要： | 应用蝮蛇抗栓酶(由江浙蝮蛇毒中提取)治疗心血管疾病40例,剂量为0.01-0.02U/kg,稀释后静滴,qd,21d为一疗程。治疗后患者的全血和血浆粘度、血小板聚集率、纤维蛋白原含量和血脂浓度均有显著下降。另有类似的40例患者用曲克芦丁400mg/d,静滴,21d为一疗程作对照,结果发现蝮蛇抗栓酶组(包括临床疗效)均明显优于对照组,且不良反应轻微,未发现肝、肾功能障碍和明显出血倾向。
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| 关 键 词： | 蛇毒类 抗凝血酶类 芦丁 心血管疾病 流变学 |
Ahalysantinfarctase modifying the cardiovascular disease in 40 patients |
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| YANG Ju-Xian,HOU Ren-Jun,XU Ji-Min,HUANG Zhen-Hua,FENG Shi-Min WANG Min.Ahalysantinfarctase modifying the cardiovascular disease in 40 patients[J].Chinese Journal of New Drugs and Clinical Remedies,1990(1). |
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| Authors: | YANG Ju-Xian HOU Ren-Jun XU Ji-Min HUANG Zhen-Hua FENG Shi-Min WANG Min |
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| Abstract: | A preparation of ahalysantinfarctase (from snake venom of the Pallas pit viper in Jiangsu and Zhejiang Provinces), 0.01-0.02 U/kg, for intravenous drip after dilution once daily, 21 d as a course of treatment, was given to 40 patients with various cardiovascular disease The blood and plasma viscosity, the fibrinogen content, the rate of platelet aggregation and the blood Hpid's concentration were all decreased significantly following the medication. Another 40 patients with similar disease receiving troxerutin, 400 mg/d, also via intravenous drip, however had less remarkable advantages.Clinical efficacy was far better in the former than in the latter. The adverse reactions were mild, no hepatic or renal impairments and no marked bleeding tendency were observed |
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| Keywords: | snake venoms antithrombins rutin cardiovascular diseases rheology |
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