Angiotensin II signal transduction: Stimulation of multiple mitogen-activated protein kinase pathways. |
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| Authors: | U Schmitz B C Berk |
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| Affiliation: | Department of Medicine, Cardiology Division, University of Washington, Seattle, WA 98195, USA. |
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| Abstract: | Angiotensin II (AngII)( *) is the main effector of the renin-angiotensin system and influences cell growth, migration, differentiation, and apoptosis. The mitogen-activated protein (MAP) kinase family of serine-threonine kinases integrates diverse extracellular stimuli and is involved in the regulation of cell growth and apoptosis. AngII regulates activity of the MAP kinase family members extracellular regulated kinases (ERK1/2) and c-Jun N-terminal kinase (JNK). This review discusses the signal transduction pathways leading to ERK1/2 and JNK activation by AngII. |
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