RECK、VEGF和MVD在非小细胞肺癌中的表达及其相关性

[目的]探讨RECK与血管内皮生长因子(VEGF)、微血管密度(MVD)在非小细胞肺癌(NSCLC)中的表达和相关性.[方法]采用免疫组化SP法检测80例肺癌组织和20例癌旁正常肺组织中RECK、VEGF和MVD的表达水平.[结果]NSCLC中RECK的表达低于癌旁组织(36.25％vs 85.00％,P=0.0001),VEGF(68.75％vs 35.00％,P=0.005)和MVD(20.94±8.76 vs 10.57±4.24,P=0.0001)的表达高于癌旁组织.RECK表达在鳞癌和中、低分化的肿瘤中降低;VEGF在腺癌中表达增高；MVD值在年龄小于60岁患者中增高.VEGF表达与MVD呈正相关；RECK表达与MVD呈负相关.多变量Logistic回归分析显示RECK蛋白表达下调是NSCLC预后不良因素.[结论]RECK、VEGF、MVD表达在NSCLC中有一定相关性,RECK低表达是NSCLC独立不良预后因素.

The Expression of RECK,VEGF and MVD in Non-small Cell Lung Cancer and Their Correlation

[Purpose] To investigate the expression of RECK,VEGF and MVD in non-small cell lung cancer(NSCLC) and their correlation.[Methods] The expression of RECK,VEGF and MVD in 80 NSCLC tissues and 20 adjacent tissues was detected by immunohistochemical SP method.[Results] RECK-expression in cancer tissues was higher than that in adjacent tissues(26.25% vs 85.00%,P= 0.0001),VEGF-expression and MVD were lower than those in adjacent tissues(68.75% vs 35.00%,P= 0.005;20.94±8.76 vs 10.57±4.24,P=0.0001).RECK-expression decreased in squamous cell carcinomas and in medium/low differentiation tumors.VEGF-expression increased in adenocarcinoma.MVD value increased in patients less than 60 years old.VEGF-expression was positively correlated with MVD.RECK-expression was negatively correlated with MVD.Multivariable Logisitic regression analysis showed that low expression of RECK protein was poor prognosis factor.[Conclusion] The expression of RECK,VEGF and MVD is certainly correlated to NSCLC.Low expression of RECK is a poor prognosis factor.