| 长春瑞滨联合顺铂治疗晚期非小细胞肺癌临床观察 |
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| 引用本文： | 胡志萍,甘宁,陈焕朝. 长春瑞滨联合顺铂治疗晚期非小细胞肺癌临床观察[J]. 现代中西医结合杂志, 2007, 16(24): 3467-3468 |
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| 作者姓名： | 胡志萍 甘宁 陈焕朝 |
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| 作者单位： | 湖北省肿瘤医院,湖北,武汉,430079 |
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| 摘 要： | 目的观察长春瑞滨(NVB)与顺铂(DDP)联合化疗对非小细胞肺癌的疗效和毒副反应。方法36例患者予NVB 25 mg/m2于第1,8天静脉滴注,DDP 60 mg/m2分3~5 d静脉滴注,21 d为1个周期,对疗效及毒副反应进行评价。结果36例均化疗2个周期以上,完全缓解(CR)1例,部分缓解(PR)15例,总缓解率(CR+PR)为44%。主要毒副反应为骨髓抑制,Ⅲ~Ⅳ度血白细胞下降占56%(16/36)。结论长春瑞滨联合顺铂化疗方案对晚期非小细胞肺癌有一定的肿瘤客观缓解率,毒副反应耐受性好,值得临床推广。
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| 关 键 词： | 晚期非小细胞肺癌 长春瑞滨 顺铂 化学疗法 |
| 文章编号： | 1008-8849（2007）24-3467-02 |
| 收稿时间： | 2007-01-10 |
| 修稿时间： | 2007-01-10 |
Clinical observation of vinorelbine Combined with cisplatin in the treatment of advanced non-small cell lung cancer |
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| HU Zhi-ping,GAN Ning,CHEN Huan-chao. Clinical observation of vinorelbine Combined with cisplatin in the treatment of advanced non-small cell lung cancer[J]. Modern Journal of Integrated Chinese Traditional and Western Medicine, 2007, 16(24): 3467-3468 |
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| Authors: | HU Zhi-ping GAN Ning CHEN Huan-chao |
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| Affiliation: | The Cancer Hospital of Hubei Province, Wuhan 430079, Hubei, China |
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| Abstract: | Objective It is to observe the influence of the curative effect and adverse effects of vinorelbine and cisplatin in the treatment of advanced non-small cell lung cancer(NSCLC).Methods 36 patients with advanced NSCLC were accepted chemotherapy by vinorelbine 25 mg/m2 was dropped in 1st and 8th day and cisplatin 60 mg/m2 was dropped in 3 to 5 days,21 days/cycle.The curative effect and adverse effects were evaluated.Results 36 patients were all accepted 2 cycle chemotherapy at least.There was 1 case in CR and 15 cases in PR and the total remission rate was 44%.The main adverse effects were myelosuppression,the rat of blood cell decrease Ⅲ and Ⅳ grade was 56%(20/36).Conclusion The chemotherapy of vinorelbine combine with cisplatin is effective in advanced NSCLC. |
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| Keywords: | advanced non-small cell lung cancer vinorelbine cisplatin chemotherapy |
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