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Hepatocellular carcinoma and the risk of occupational exposure
Authors:Venerando Rapisarda  Carla Loreto  Michele Malaguarnera  Annalisa Ardiri  Maria Proiti  Giuseppe Rigano  Evelise Frazzetto  Maria Irene Ruggeri  Giulia Malaguarnera  Nicoletta Bertino  Mariano Malaguarnera  Vito Emanuele Catania  Isidoro Di Carlo  Adriana Toro  Emanuele Bertino  Dario Mangano  Gaetano Bertino
Abstract:Hepatocellular carcinoma (HCC) is the most common type of liver cancer. The main risk factors for HCC are alcoholism, hepatitis B virus, hepatitis C virus, nonalcoholic steatohepatitis, obesity, type 2 diabetes, cirrhosis, aflatoxin, hemochromatosis, Wilson’s disease and hemophilia. Occupational exposure to chemicals is another risk factor for HCC. Often the relationship between occupational risk and HCC is unclear and the reports are fragmented and inconsistent. This review aims to summarize the current knowledge regarding the association of infective and non-infective occupational risk exposure and HCC in order to encourage further research and draw attention to this global occupational public health problem.
Keywords:Hepatocellular carcinoma   Autophagy   Epigenetic events   Hepatitis B virus   Hepatitis C virus   Occupational exposure   Chemical agents   Mitophagy   Arsenic   Cadmium
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