N-三甲基壳聚糖对丙酸倍氯米松凝胶体外促透作用的考察

目的：考察N-三甲基壳聚糖（TMC60）对丙酸倍氯米松（BM）的体外促透作用。方法：制备含1％TMC60的BM凝胶，用Frartz扩散池进行体外促透作用研究，以稳态透皮速率J为指标，与同浓度的氮酮、壳聚糖（CS）进行比较。结果：空白组、氮酮组、TMC60组及CS组的J分别为3．8221，4．0984，4．2055和4．3569ug·cm^-2·h^-1。与空白组相比，TMC60有显著的促进BM体外透皮扩散作用（P〈0．05）；而与同浓度氮酮、CS相比，促透作用无显著性差异（P〉0．05）。结论：TMC60可显著促进BM的体外透皮扩散。

Study on the Transdermal Permeation Enhancement of N-trimenthyl Chitosan on Beclomethasome Dipropionate Gels in vitro

Objective： To study the enhancement of N-trimethyl chitosan （TMC 60） on cutaneous absorption of beclomethasome dipropionate （BM） gel in vitro. Method： BM gel with 1% TMC60 was prepared as enhancer. Compared with the stability penetration rate （J, ug·cm^-2·h^-1） of Azone and chitosan （CS） with the same concentration, the enhancement of TMC 60 was studied by Franz Diffusion Cells in vitro. Result： J of BM gels without any enhancer and with Azone, TMC60 and CS as enhancer were3. 8221,4.0984, 4.2055 and 4.3569, respectively. Compared with blank group, TMV60 had significant enhancement （ P 〈 0.05 ） while compared with Azone and CS group, TMC 60 had no significant difference（ P 〉0. 05 ）. Conclusion： 1% TMC 60 can enhance cutaneous absorption of BM with similar effect with 1% Azone and CS.