| Affiliation: | (1) Laboratory for Mechanisms of Atherogenesis, Institute of Experimental Cardiology, Russian Research-and-Production Complex for Cardiology, Russian Ministry of Health, USSR;(2) Institute of Atherosclerosis, Russian Academy of Natural Sciences, Moscow |
| Abstract: | The state of apo-B in native and circulating modified low-density lipoproteins was studied by solid-phase enzyme immunoassay. We studied the interaction of these particles with monoclonal antibodies to apo-B of low-density lipoproteins. Native and circulating modified low-density lipoproteins had different affinity for the studied antigens. Our results illustrate conformational changes in apo-B of circulating modified low-density lipoproteins compared to native low-density lipoproteins. These changes probably contribute to increased accumulation of particles in vascular cells and their transformation into foam cells giving way to atherosclerotic vascular lesions. Translated fromByulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 138, No. 7, pp. 50–53, July, 2004 |
