口腔癌及癌前病变中FHIT与cyclinD1/CDK4表达的相关性研究 |
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摘 要: |
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关 键 词: | FHIT cyclin D1 CDK4 口腔癌 癌前病变 |
Expressions of FHIT and cyclin D1/CDK4 in oral cancer and oral precancerous lesions] |
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Authors: | Cao Yin Li-jia Shen Si-ming Xie Ping Ruan Xi Yao |
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Affiliation: | Guangdong Provincial Stomatological Hospital, Guangzhou 510280, China. yin9731@hotmail.com |
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Abstract: | OBJECTIVE: To detect the expressions of fragile histidine triad (FHIT) and cyclin D1/CDK4 in oral squamous cell carcinoma (OSCC) and oral precancerous lesions and investigate the relationship between the expressions and the histopathological changes. METHODS: Immunohistochemical staining by SP methods was utilized to detect the expression of FHIT and cyclin D1/CDK4 in 64 cases of OSCC, 39 oral precancerous lesions and 12 normal oral mucosa specimens. RESULTS: The rate of the negative or low FHIT expression in OSCC was 17% (11/64), which was remarkably lower than that in normal oral membrane and oral precancerous lesions (P<0.01). Significantly higher levels of cyclin D1/CDK4 expressed in OSCC than in normal oral membrane and precancerous lesions (P<0.01). There was no significant correlation between FHIT and cyclin D1/CDK4, and positive correlation between cyclin D1 and CDK4 was observed. CONCLUSION: FHIT, cyclin D1 and CDK4 may play a role in the pathogenesis of OSCC, and FHIT can down-regulate the expression of cyclin D1. |
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