Morphologic Study of the Participation of the Complement System in Hyperacute Rejection of Renal Xenotransplants |
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| Authors: | Jaime E Mej¯a-Laguna Adolfo Mart¯nez-Palomo Carlos E Biro Bibiana Ch¬vez Fernando LÌpez-Soriano and Marcelo Garc¯a-Cornejo |
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| Institution: | Jaime E. Mej?a-Laguna, Adolfo Mart?nez-Palomo, Carlos E. Biro, Bibiana Ch?vez, Fernando L?pez-Soriano, and Marcelo Garc?a-Cornejo |
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| Abstract: | The role of polymorphonuclear leukocyte (PMN) and platelet infiltration in the hyperacute rejection of renal xenotransplants was studied. In a first group, a dog kidney was grafted to rabbit recipients with intact immune adherence and chemotaxis. A second group included recipients depleted of PMN's with nitrogen mustard, and in a third group, immune adherence and chemotaxis were modified by depleting the third component of complement by means of cobra venom factor. Serial kidney biopsies were studied with light and electron microscopic technics. A semiquantitative evaluation of PMN and platelet glomerular infiltration indicated that a reduction in the number of PMN's or platelets is associated with an increased survival time of the transplanted kidney. |
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