Frequency and diagnostic value of the virus-like filamentous intranuclear inclusions in giant cell tumor of bone,not associated with Paget's disease |
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| Authors: | René Abelanet Monique Daudet-Monsac Saddek Laoussadi Michel Forest Marie-Cécile Vacher-Lavenu |
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| Affiliation: | (1) Service Central d'Anatomie et Cytologie pathologiques, Hopital Cochin, 27 Rue du Faubourg Saint jacques, F-75674 Paris, Cedex 14, France |
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| Abstract: | Summary This paper deals with the paramyxovirus-like intranuclear inclusions observed in giant cells tumours of bone (GCTB). Twenty-one (49%) of 43 cases of GCTB (1977–1985), either fresh and/ or cultured, show these ultrastructural inclusions.Fifty samples of various bone lesions in which giant cell lesions occurred, including aneurysmal cysts, hyperparathyroidism, osteoblastoma, human and rat osteopetrosis, GCT of tendon sheaths, and non skeletal granuloma were used as controls. These, together with 20 samples of normal bone (osteoclasts) did not contain intranuclear or intracytoplasmic viral inclusions. |
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| Keywords: | Giant-cell Virus-like inclusion Intranuclear inclusion Giant cell tumour of bone Paget's disease of bone Electron microscopy |
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