Prognostic value of resection margins in supracricoid laryngectomy |
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Authors: | Gallo Andrea Manciocco Valentina Tropiano Maria Luisa Simonelli Marilia Marvaso Vincenzo D'Arcangelo Enzo de Vincentiis Marco |
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Affiliation: | Department of Otorhinolaryngology, La Sapienza University, Rome, Italy. andrea.gallo@uniroma1.it |
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Abstract: | OBJECTIVES: The objective was to assess the prognostic value of surgical margin involvement in patients treated for squamous cell carcinoma of the larynx. STUDY DESIGN: Retrospective study. METHODS: A review was made of 253 patients treated with supracricoid laryngectomy between 1984 and 2001. A histopathological study on the surgical resection margins was performed in all cases. The incidence of local recurrence was correlated with the histological features of resection margins. RESULTS: Forty patients (15.8%) were identified as having positive margins: 29 had invasive carcinoma and 11 had dysplastic lesions. The remaining 213 patients (84.2%) had negative margins. Subsequent follow-up showed that 19 of 253 patients developed local recurrence and 3 patients developed regional recurrence. Nine of these patients had positive resection margins (six with invasive carcinoma and three with dysplastic lesions), and 10 had negative resection margins. Overall survival at 3 years was significantly higher for patients without recurrence than for patients with local or regional failure (89.9% vs. 45.5% [P <.05]). CONCLUSION: According to results of the study, patients with positive resection margins developed local recurrence more frequently than those with clear resection margins (P <.05). |
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Keywords: | Resection margins supracricoid laryngectomy laryngeal cancer prognosis laryngeal recurrences |
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