超声造影监测兔肾缺血再灌注前后肾皮质、髓质血流灌注

目的 探讨兔肾缺血再灌注损伤(IRI)前后肾皮质、髓质血流灌注变化的CEUS特征.方法 建立12只兔肾IRI模型,分别于缺血前及再灌注24 h后行CEUS检查,并对造影的时间—强度曲线(TIC)各参数进行分析.结果 肾皮质缺血前TIC上升支斜率(Grad)明显高于再灌注24 h后(P＜0.05),开始增强时间(AT)、...

Contrast-enhanced ultrasound in monitoring renal cortical and medullary perfusion in ischemia reperfusion injury on rabbit models

Objective To observe CEUS characteristics of renal cortical and medullary before and after renal ischemia reperfusion injury (IRI) on rabbit models. Methods The model of renal IRI were established in 12 rabbits. CEUS was performed on each rabbit before and 24 h after model establishment. The characteristics of parameters of renal perfusion time-intensity curve (TIC) was analyzed. Results The value of gradient between start frame to peak frame (Grad) renal cortical before IRI was significantly higher than that after IRI (P<0.05). The value of arrival time (AT), time to peak intensity (TTP) and area under the cure (AUC) of renal cortical were significantly lower than those after IRI (P<0.05), no significant difference was found in difference between B and the intensity at t=0 (A) of renal cortical before and after IRI (P>0.05). The value of TTP and AT renal medullary before IRI were significantly higher than those after IRI (P<0.05), no significantly difference was found in A, AUC, Grad of renal medullary before and after IRI (P>0.05). Conclusion CEUS monitoring rabbits renal cortical is able to detect changes of perfusion of renal IRI sensitively with the help of analysis of TIC. It can provide some experimental basis for clinical noninvasive evaluating on renal injury.