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Hypoxia-Inducible Vascular Endothelial Growth Factor Gene Therapy Using the Oxygen-Dependent Degradation Domain in Myocardial Ischemia
Authors:Hyun Ah Kim  Soyeon Lim  Hyung-Ho Moon  Sung Wan Kim  Ki-Chul Hwang  Minhyung Lee  Sun Hwa Kim  Donghoon Choi
Affiliation:(1) Department of Bioengineering, College of Engineering, Hanyang University, Seoul, 133-791, Korea;(2) Severance Integrative Research Institute for Cerebral and Cardiovascular Disease, Yonsei University Health System, 250 Seongsanno, Seodaemun-gu, Seoul, 120-752, South Korea;(3) Center for Controlled Chemical Delivery, Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, Utah 84112, USA;
Abstract:

Purpose  

A hypoxia-inducible VEGF expression system with the oxygen-dependent degradation (ODD) domain was constructed and tested to be used in gene therapy for ischemic myocardial disease.
Keywords:
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