| 佐剂关节炎大鼠心功能变化与细胞因子、调节T细胞和Foxp3表达的相关性 |
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| 引用本文： | 朱艳,刘健,曹云祥.佐剂关节炎大鼠心功能变化与细胞因子、调节T细胞和Foxp3表达的相关性[J].中国康复,2011,26(1):6-9. |
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| 作者姓名： | 朱艳 刘健 曹云祥 |
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| 作者单位： | 1. 湖北中医药大学,武汉,430001
2. 安徽省中医院风湿免疫科,合肥,230038 |
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| 基金项目： | 国家中医药重点学科中医痹病学建设项目，安徽省科技厅科研计划项目，安徽省卫生厅中医药科研项目，安徽中医内科应用基础与开发研究省级实验室项目，安徽省教育厅自然科学重点科研项目，安徽中医学院科技创新团队项目 |
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| 摘 要： | 目的:观察佐剂性关节炎(adjuvant arthritis,AA)大鼠足跖肿胀度(E)、关节炎指数(AI)、心功能、细胞因子、调节T细胞及Foxp3的表达,探讨细胞因子、转录因子Foxp3与调节T细胞(Treg)在AA大鼠心功能改变中的作用机制.方法:24只Wistar雄性大鼠随机分为正常组和模型组(Model组)各...
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| 关 键 词： | 佐剂性关节炎 心功能 细胞因子 Foxp3的表达 调节T细胞 |
Cardiac Function in Rats with Adjuvant Arthritis and Its Relationship with Cytokines, Regulatory T Cells and the Expression of Foxp3 |
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| ZHU Yan,LIU Jian,CAO Yun-xiang.Cardiac Function in Rats with Adjuvant Arthritis and Its Relationship with Cytokines, Regulatory T Cells and the Expression of Foxp3[J].Chinese Journal of Rehabilitation,2011,26(1):6-9. |
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| Authors: | ZHU Yan LIU Jian CAO Yun-xiang |
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| Institution: | ZHU Yan,LIU Jian,CAO Yun-xiang.Doctorial Graduate Class of 2008,Hubei University of Traditional Chinese Medicine,Wuhan 430001,China |
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| Abstract: | Objective:To observe paw swelling(E) and arthritis index(AI),cardiac function,cytokines,regulatory T cells(Tregs) and the expression of Foxp3 in rats with adjuvant arthritis(AA).Methods:Twenty-four Wistar male rats were randomly divided into normal control(NC) group and AA model group,12 in each group.The AA model was established by intradermal injection of Freund's complete adjuvant(FCA) in the right paw in the AA model group.One day before,and 18 and 32 days after AA establishment,body weight,E and AI wer... |
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| Keywords: | adjuvan tarthritis cardiac function cytokines foxp3 expression regulatory T cells |
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