犬急性肠系膜缺血介入模型的建立

目的 建立一种适合于影像学研究的犬急性肠系膜缺血新模型。方法 10只比格犬分为缺血组(8只)和对照组(2只),将4F Cobra导管选择性插入肠系膜上动脉。缺血组对肠系膜上动脉分支行无水乙醇栓塞术,对照组注射相同剂量生理盐水,之后行影像学观察和病理学研究。结果 数字减影血管造影显示缺血组肠系膜上动脉部分分支血管闭塞,对照组肠系膜上动脉血管无变化;CT和病理学观察缺血组出现急性肠缺血征象,对照组表现正常。结论 采用选择性插管无水乙醇栓塞技术可建立适合影像学研究的急性肠系膜缺血模型。

Establishment of canine models of acute mesenteric ischamia

Objective To establish a new canine model of acute mesenteric ischemia for imaging studies. Methods Ten Beagle dogs were divided into ischemic group (n=8) and control group (n=2). Via a 4F Cobra catheter, the absolute ethanol was selectively injected into the superior mesenteric artery (SMA) for embolization in the former group while the saline was injected in the latter. Imaging study and pathological examination were performed. Results Digital subtraction angiography (DSA) revealed that occlusion of some branches of the SMA was induced in the ischemic group while no changes occurred in the control group. The signs of acute mesenteric ischemia were confirmed by CT and pathological examination in the ischemic group whereas no abnormalities identified in the group. Conclusion Canine models of acute mesenteric ischemia can be established by selective catheterization with absolute ethanol injection.