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Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells
Affiliation:1. Complement and Inflammation Research Section (CIRS), National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD 20892, USA;2. Immunoregulation Section, Kidney Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), NIH, Bethesda, MD 20892, USA;3. Viral Immunology & Intravital Imaging Section, National Institute of Neurological Disorders and Stroke (NINDS), NIH, Bethesda, MD 20892, USA;4. Department of Biomedicine, Immunobiology, University Hospital and University of Basel, Basel 4031, Switzerland;5. Institute of Immunology and Immunotherapy, University of Birmingham, Birmingham B15 2TT, UK;6. Infection, Immunity, Inflammation Programme, University College London (UCL) Great Ormond Street Institute of Child Health, London WC1N 1EH, UK;7. Arthritis Research UK Centre for Adolescent Rheumatology at UCL, UCHL and GOSH, London WC1N 1EH, UK;8. National Institute for Health Research (NIHR) Biomedical Research Centre at Great Ormond Street NHS Foundation Trust, London WC1N 1EH, UK;9. Inflammation and Innate Immunity Unit, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD 20892, USA;10. School of Immunology and Microbial Sciences, Faculty of Life Sciences and Medicine, King’s College London, London SE1 9RT, UK;11. Departments of Biochemistry and Computer Science, Purdue University, West Lafayette, IN 47907, USA;12. Systemic Autoimmunity Branch, National Institute of Arthritis and Musculoskeletal and Skin Disease (NIAMS), NIH, Bethesda, MD 20892, USA;13. Oral Immunity and Inflammation Unit, National Institute of Dental and Craniofacial Research (NIDCR), NIH, Bethesda, MD 20892, USA;14. Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD 20892, USA;15. Department of Medicine, University of Cambridge, Cambridge CB2 0AW, UK;16. Institute for Systemic Inflammation Research, University of Lübeck, Lübeck 23562, Germany
Abstract:
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  • Keywords:intracellular complement  complosome  T cells  LFA-1  autoimmunity  integrins  metabolism  Th1 cells  lymphocyte adhesion deficiency type 1  LAD-1  biomarker
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