Associations between smoking,glucose metabolism and lipid levels: A cross-sectional study |
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| Affiliation: | 1. Department of Health Science and Technology, Aalborg University, Aalborg, Denmark;2. Novo Nordisk A/S, Hilleroed, Denmark;3. Steno Diabetes Center, Gentofte, Denmark;4. Department of Endocrinology and Internal Medicine/Medical Research Laboratory, Aarhus University Hospital, Denmark;5. Nordsjaellands Hospitaler, Hilleroed, Denmark;1. Division of Pediatric Cardiology, Department of Pediatrics, University of Colorado – School of Medicine, Aurora, CO, United States of America;2. Section of Pediatric Endocrinology, Department of Pediatrics, University of Colorado – School of Medicine, Aurora, CO, United States of America;3. Section of Endocrinology, Rocky Mountain Regional VAMC, CO, United States of America;4. Division of Endocrinology, Department of Medicine, United States of America;5. Center for Women''s Health Research, University of Colorado – School of Medicine, Aurora, CO, United States of America;1. Cincinnati Children''s Hospital Medical Center and the University of Cincinnati, United States of America;2. Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America;3. Department of Epidemiology, Colorado School of Public Health, University of Colorado Denver, Aurora, CO, United States of America;4. Division of Health Services Research, NYU Long Island School of Medicine, Mineola, NY, United States of America;5. Department of Biostatistics and Data Science, Wake Forest School of Medicine, Winston-Salem, NC, United States of America;6. Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC, United States of America;7. Department of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, United States of America;8. Seattle Children''s Hospital, Seattle, WA, United States of America |
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| Abstract: | AimsThe aim of this study was to investigate glucose profiles assessed by oral glucose tolerance tests (OGTT), fasting glucose, and lipid profiles among smokers, ex-smokers and never-smokers.Materials and methodsThe study design used was a cross-sectional analysis of data from several years of the NHANES (National Health and Nutrition Examination Survey) from 2005 to 2014. A total of 12,460 participants with measures of OGTT, triglycerides, LDL-cholesterol and HDL-cholesterol were included for the data analysis. Outcomes were all assessed in an unadjusted and in an adjusted gender analysis. A GLM model was used to assess 2-hour OGTT, fasting plasma glucose, difference between fasting plasma glucose and OGTT, HbA1c, HDL-cholesterol, LDL-cholesterol, and triglyceride in relation to current smoking, ex-smoking and never smoking. The effects were adjusted with covariates: gender, BMI, age, alcohol usage, educational level and ethnicity.ResultsThe OGTT results was lower for the group smoking (−10.1 [−13.2; −7.1], p < 0.001), and no effect was observed from ex-smoking (−2.7 [−5.7; 0.8], p = 0.08). Fasting glucose was not different for smokers (−0.2 [−1.6; 1.2], p = 0.80) or ex-smokers (0.1 [−1.3; 1.5], p = 0.90). For smokers', triglycerides (1.2 [1.1; 1.3], p < 0.001), LDL-cholesterol (7.7 [6.0; 9.3], p < 0.001) were increased and HDL-cholesterol was decreased (−2.1 [−2.8; −1.5], p < 0.001).ConclusionsAlthough this study is cross-sectional and cannot, by the same nature of the design, prove a cause-effect relationship, the present results indicate that cigarette smoking may be associated with factors that are adversely related to the metabolic syndrome. But the evidence from our results are not unanimous pointing in the same direction as 2-hour OGTT measurements are considerably lower in participants smoking. |
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