Albuminuria and other target organ damage in Chinese patients with hypertension and diabetes: A data analysis based on the ATTEND study |
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| Institution: | 1. Department of Endocrinology and Metabolism, Peking University People''s Hospital, Beijing, PR China;2. Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China;3. Centre for Epidemiological Studies and Clinical Trials, Shanghai Key Laboratory of Hypertension, The Shanghai Institute of Hypertension, Department of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, PR China;4. Department of Endocrinology, Peking University First Hospital, Beijing, PR China;1. Department of Internal Medicine, University of Tennessee Health Science Center, Memphis, TN, USA;2. Division of Cardiovascular Medicine, Department of Internal Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, CA, USA;3. Division of Endocrinology and Metabolism, University of Tennessee Health Science Center, Memphis, TN, USA;4. Methodist University Hospital, Memphis, TN, USA;5. John Hopkins School of Medicine, Baltimore, MD, USA;6. Division of Cardiovascular Medicine, Lehigh Valley Healthcare Network, Philadelphia, PA, USA;7. Division of Cardiovascular Medicine, University of Tennessee Health Science Center, Memphis, TN, USA;8. Department of Internal Medicine, University of Arizona Medical School-Phoenix, AZ, USA;1. Steno Diabetes Center Copenhagen, Niels Steensens Vej 2, 2820 Gentofte, Denmark;2. Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 3B, 2200 Copenhagen N, Denmark |
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| Abstract: | AimsThe relationship between albuminuria and left ventricular hypertrophy (LVH) was well characterized in hypertension (HTN), but not in diabetes. Moreover, most studies have described the correlation between albuminuria and cardiovascular mortality, but not cardiovascular diseases (CVD) morbidity. This study aimed to explore the relationship between albuminuria and LVH, CVD morbidity in patients with HTN, diabetes mellitus (DM) or HTN + DM.MethodsConducted a data analysis based on the demographic, medical history and laboratory data of 2504 patients from the ATTEND study, a national registry study on HTN and DM in Chinese outpatients.ResultsThe prevalence of LVH and CVD was 7.7% and 21.5% in HTN + DM, 7.6% and 17.6% in HTN, 3.9% and 5.2% in DM patients. Subjects with HTN + DM implied higher risk of LVH (P = 0.023), CVD (P = 0.001) and 10-year coronary heart disease (CHD) (P < 0.001) than those with DM only. There was no significant relationship between albuminuria and LVH or CVD.ConclusionsMore than one-fifth of HTN and/or DM patients with microalbuminuria suffered from CVD. Comorbidity of DM and HTN significantly increases cardiovascular events than DM only. No statistical association between albuminuria and LVH or CVD was found. |
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