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Skeletal deterioration in COL2A1-related spondyloepiphyseal dysplasia occurs prior to osteoarthritis
Affiliation:2. Department of Osteology and Biomechanics, University Medical Center Hamburg-Eppendorf, Lottestr. 59, 22529, Hamburg, Germany;3. Department of Orthopedics, University Medical Center Hamburg-Eppendorf, Hamburg, Germany;4. Institute of Medical Genetics and Human Genetics, Charité-Universitätsmedizin Berlin, Berlin, Germany;6. Berlin-Brandenburg School for Regenerative Therapies, Charité-Universitätsmedizin Berlin, Berlin, Germany;5. Max Planck Institute for Molecular Genetics, FG Development and Disease, Berlin, Germany;11. Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
Abstract:
Keywords:Skeletal dysplasia  Early-onset osteoarthritis  Osteoporosis  Bone turnover  Mouse model
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