A Population-Based,Nationwide Longitudinal Study of Bipolar Disorder With Incident Dementia in Taiwan |
| |
| Institution: | 1. Department of Psychiatry, Taipei Veterans General Hospital (S-HL, C-MC, S-JT, C-FT, Y-M, T-PS, C-TL, W-CL, M-HC), Taipei, Taiwan;2. Department of Psychiatry, College of Medicine, National Yang-Ming University (C-MC, S-JT, C-FT, Y-M, T-PS, C-TL, W-CL, M-HC), Taipei, Taiwan;3. Department of Family Medicine, Taipei Veterans General Hospital (T-JC), Taipei, Taiwan;4. Institute of Hospital and Health Care Administration, National Yang-Ming University (T-JC), Taipei, Taiwan;5. Department of Psychiatry, Cheng Hsin General Hospital (T-PS), Taipei, Taiwan;6. Department of Psychiatry, Taipei Veterans General Hospital (C-MC), Taipei, Taiwan;1. Massachusetts General Hospital (EB), Boston, MA;2. Harvard Medical School (EB), Boston, MA;3. University Côte d''Azur (PR), Nice, France;1. Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden;2. Department of Pharmacology (EE) Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden;3. Clinical Neurochemistry Lab, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Sweden;4. Department of Molecular Neuroscience, UCL Institute of Neurology, London, UK;2. Research Center for Chinese Herbal Medicine and Research Center for Food and Cosmetic Safety, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan, Taiwan;3. Liver Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan;4. Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan;6. Department of Psychiatry, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;5. Department of Psychiatry, Cheng Hsin General Hospital, Taipei, Taiwan;11. Department of Psychiatry, Beitou Branch, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan;12. Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan;1. Department of Psychiatry, Far Eastern Memorial Hospital, New Taipei City, Taiwan;2. School of Medicine, National Yang-Ming University, Taipei, Taiwan;3. Division of Medical Image, Far Eastern Memorial Hospital, New Taipei City, Taiwan;4. Department of Healthcare Administration, College of Health Science, Asia University, Taichung, Taiwan |
| |
| Abstract: | ObjectiveAffective disorders are associated with increased risk of dementia, yet most studies focus on the association of major depressive disorder or depressive episodes of bipolar disorder with increased dementia risk. The association of manic/mixed episodes of bipolar disorder with increased dementia risk is unclear.ParticipantsBetween January 1, 2001 and December 31, 2009, 20,535 individuals aged 45–80 years with bipolar disorder and 82,140 age- and sex-matched comparisons were enrolled and followed up to December 2011 in Taiwan. Those who developed dementia (ICD-9-CM codes: 290.0–290.4, 294.1–294.2, and 331.0–331.2) during the follow-up period were identified.Design and MethodsCox proportional hazards models were used to examine the relationship between manic/mixed/depressive episodes of bipolar disorder and incident dementia. We also assessed the association between the frequency of psychiatric admissions (total, manic/mixed, and depressive episodes per year) for bipolar disorder and dementia risk.ResultsBipolar disorder was associated with increased risk of incident dementia (hazard ratio HR]: 7.52, 95% confidence interval CI]: 6.86–8.25). Greater frequency of manic/mixed (>2/year: HR: 4.50, 3.50–5.79; 1–2/year: HR: 3.17, 2.31–4.36) and depressive episodes (>2/year: HR: 7.84, 5.93–10.36; 1–2/year: HR: 2.93, 2.05–4.19) were associated with increased risk of incident dementia.ConclusionsNot only depressive episode of bipolar disorder, but manic/mixed episodes of bipolar play a role as a risk factor of incident dementia, especially for those patients with more than two manic/mixed episodes per year. These findings remind the clinicians the importance of preventing the relapse of bipolar disorder for the potential subsequent cognitive decline and disease. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
