Sex difference in the association between surrogate markers of insulin resistance and arterial stiffness |
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| Institution: | 1. Department of Cardiovascular Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan;2. Chiba Foundation for Health Promotion & Disease Prevention, 32-14 Shinminato, Mihama-ku, Chiba 261-0002, Japan;3. Biostatistics Section, Clinical Research Center, Chiba University Hospital, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan;1. Medical Care (physical examination) Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;2. Department of Endocrinology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China;3. Department of Endocrinology, Peking University International Hospital, Beijing 102206, China;4. Diabetes Center, Department of Endocrinology, The 306th Hospital of PLA, Beijing, China;5. Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, China;6. Department of Endocrinology and Metabolism, Peking University People''s Hospital, Beijing 100044, China;1. Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People''s Republic of China;2. Department of Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People''s Republic of China;3. Department of Nutrition and Food Hygiene, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People''s Republic of China;4. The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People''s Republic of China;5. Department of Mental Health, Bao''an Chronic Diseases Prevent and Cure Hospital, Shenzhen, Guangdong, People''s Republic of China;1. Department of Pediatric Endocrinology, University of Colorado School of Medicine, Aurora, CO, United States;2. Division of Pediatric Cardiology, University of Colorado School of Medicine, Aurora, CO, United States;3. Department of Biostatistics and Informatics, Colorado School of Public Health, Aurora, CO;4. Division of Cardiology, University of Colorado School of Medicine, Aurora, CO, United States;5. Center for Women''s Health Research, Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States;6. Divisions of General Internal Medicine and Cardiology, University of Colorado School of Medicine, Aurora, CO, United States;7. Division of Endocrinology, Veterans Administration Hospital, University of Colorado School of Medicine, Aurora, CO, United States |
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| Abstract: | AimsTo investigate the predictive capability of insulin resistance surrogate markers for insulin resistance and arterial stiffness based on sex.MethodsWe assessed the association of triglyceride glucose (TyG) index, triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), visceral adiposity index (VAI), and lipid accumulation product (LAP) with homeostasis model assessment-insulin resistance (HOMA-IR) and brachial–ankle pulse wave velocity (baPWV) in both sexes.ResultsA total of 1720 men and 1098 women were evaluated. HOMA-IR showed good correlation with the TyG index (men: r = 0.47, women: r = 0.45), TG/HDL-C (men: r = 0.45, women: r = 0.41), VAI (men: r = 0.51, women: r = 0.48), and LAP (men: r = 0.55, women r = 0.49) (all p-values < 0.001). These markers positively correlated with increased baPWV in both sexes. The standardized partial regression coefficients were 0.11 and 0.14 for the TyG index, 0.13 and 0.16 for TG/HDL-C, 0.14 and 0.19 for VAI, and 0.12 and 0.17 for LAP in men and women, respectively (all p-values < 0.01; all p-values for sex interaction < 0.05).ConclusionsAll insulin surrogate markers showed good correlation with HOMA-IR in both sexes. These indices were also associated with increased baPWV and the associations were stronger in women than in men. |
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