含硫三环氟喹诺酮类化合物的合成及其抗菌活性研究

目的：寻找具有更好抗菌活性的含硫三环氟喹诺酮类化合物。方法：在芦氟沙星母核的10位引入不同基团，设计并合成8个含硫三环氟喹诺酮类化合物，并测定其体外抗菌活性。结果：合成了目标化合物，其结构经IR、^1HNMR、MS和元素分析确证；它们具有不同强度的抗菌活性，其中几个化合物的抗菌活性优于芦氟沙星。结论：初步的体外抗菌实验证实所合成目标化合物具明显的抗菌活性，甚至优于芦氟沙星。

Synthesis and Antibacterial Activity of Sulfur-containing Tricyclic Fluoroquinolones

Obstract: To search for nov el sulfur-containing tricyclic fluoroquinolone compounds with better antibacteria l activity. Methods: Different groups were introduced into the t enth position of rufloxacin parent structure, thus 8 sulfur-containing tricycli c fluoroquinolones were synthesized. And their in vitro antibacterial activities were evaluated by MICs against a variety of bacteria. Results: The target compounds were synthesized, their structures were confirmed by 1 HNMR, MS, IR spectra and elementary analysis and they showed different powers in antibacterial activity, of which some had higher activity than that of ruflox acin. Conclusion: The results of preliminary antibacterial activity test showed that the target compounds had antibacterial activity to different degree .