坚硬接骨板固定后局部骨质疏松的骨组织形态计量学的实验研究

本实验通过骨组织形态计量学的方法，对家兔完整胫骨坚硬接骨板内固定后局部骨组织的变化进行了研究，实验家兔随机分为１、２、３、４组和空白对照组，固定时间为６．８．１０和１２周。对不脱钙骨组织切片在纵切面和横切面上进行普通光和莹光分析测量。结果发现：坚硬接骨板内固定后六周时固定段骨即出现骨质疏松，发生在哈佛氏系统的骨丢失，１０周后骨内膜表面出现骨吸收、骨髓腔增大，两个表面的骨重建单位的负平衡使固定段皮质骨疏松变薄，特别是在钢板下。

Experimental study on local osteoporosis secondary to rigid plate internal fixation with bone histomor-phometry

Through bone histomorphometrical method,local bone changes of rabbit intact tibia after rigtd plate internal fixation was studied.Experimental rabbits were divided into 1,2,3,4 and blank control groups in random,with fixation time in 6,8,10 and 12 weeks respectively.Histomorphometrical and tetracycline fluorescence measurement were undertaken in non-decalcified bone tissue sections longitudinally and transversely.The results revealed that there was osteoporosis appeared at 6 weeks in rigid fixating segment.Bone lossing happened at Haver's system, bone absorption revealed after 10weeks on endosteal surface and enlargement of bone marrow. Osteoporosis and thinning of the cortex on fixating segment,especially under steel plate happened due to negative balance of remodeling process of the two surface of the bone.