Adenosine modulation of non-adrenergic non-cholinergic neurotransmission in isolated guinea-pig atria |
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Authors: | Annalisa Rubino Laura Mantelli Sandra Amerini Fabrizio Ledda |
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Affiliation: | (1) Department of Pharmacology, University of Florence, Viale G. B. Morgagni, 65, I-50134 Florence, Italy |
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Abstract: | Summary Transmural stimulation of non-adrenergic, non-cholinergic sensory nerves in guinea-pig atria, isolated from reserpine-pretreated animals, in the presence of atropine and the beta-adrenoceptor-blocking drug CGP 20712A, induced a positive inotropic effect. Adenosine (0.1–10 M) concentration-dependently reduced the cardic response to transmural nerve stimulation, without modifying the response to exogenous calcitonin gene-related peptide; the inhibitory effect of adenosine was antagonized by 1 M 8-phenyltheophylline. Moreover, the cardiac response to field stimulation was enhanced by 8-phenyltheophylline (0.1, 1 M) and by adenosine deaminase (1 g/ml), but was reduced by dipyridamole (1 M). These findings indicate the presence of inhibitory adenosine receptors on cardiac sensory nerves and suggest a modulatory effect of endogenous adenosine on cardiac non-adrenergic, non-cholinergic neurotransmission.Send offprint requests to A. Rubino at the above address |
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Keywords: | Adenosine Guinea-pig heart Sensory nerves Calcitonin gene-related peptide |
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