大肠癌中EGFR、E-cadherin 的表达及相关性研究

 目的 研究大肠癌中表皮生长因子受体（epidermal growth factor receptor, EGFR）和上皮型钙黏蛋白（E-cadherin）的表达以及它们的相关性. 方法 收集2001～2003年手术治疗的45例大肠癌的临床资料,采用免疫组织化学SP法检测大肠癌组织中EGFR、E-cadherin蛋白的表达. 结果 EGFR的表达与大肠癌的浸润深度（P〈0.05）和Duke＇s分期（P〈0.05）相关,E-cadherin的表达与大肠癌的浸润深度（P〈0.05）、Duke＇s分期（P〈0.05）及分化程度（P〈0.01）均有关,且两者表达呈显著负相关（rs＝-0.6466,P＜0.01）. 结论 EGFR、E-cadherin的表达与大肠癌的恶性行为相关,可作为大肠癌的预后判断的指标.E-cadherin表达下调可能与EGFR表达增加有关.

Study on Expression of EGFR, E-cadherin and Their Correlation in Colorectal Cancer

Objective 　To study the expression of EGFR (epidermal growth factor receptor) , E-cadherin and their correlation in colorectal cancer. Methods 　45 cases of colorectal cancer were collected . The expression of EGFR and E-cadherin was tested using immunohistochemical staining , and the expression features were analyzed. Results 　In the colorectal cancer tissue , EGFR expression was related to the invasion depth ( P < 0. 05) and Duke’s stage ( P < 0. 05) , and the expression of E2cadherin was related to the invasion depth ( P < 0. 01) , Duke’s stage ( P < 0. 05) and the degree of differentiation ( P < 0. 01) . EGFR expression was negatively related to E-cadherin expression ( rs = - 0. 6466 , P < 0. 01) . Conclusion 　The expression of EGFR and E-cadherin was related to the clinical pathologic factors , which may be regarded as a prognostic marker of colorectal cancer. The decrease of E-cadherin expression may be related to the increase of EGFR expression.