2型糖尿病周围神经病变经皮氧分压检测的临床意义

目的探讨2型糖尿病患者下肢局部经皮氧分压(TcPO2)与周围神经病变的关系。方法 115例2型糖尿病患者,其中并发神经病变患者(DPN)66例,无神经病变者49例,另健康人群对照组(Con)40例,均应用TCM雷度400经皮氧分压检测仪检测双侧膝下及足背TcPO2值,并比较各组间TcPO2值及异常率。结果 2型糖尿病并发神经病变患者(DPN)膝下及足背局部TcPO2值较2型糖尿病未合并周围神经病变者(NDPN)及正常对照组(Con)低(P<0.05)。并且健康成人组,糖尿病未合并神经病变组,糖尿病周围神经病变下肢经皮氧分压异常率人数比分别为12.5%、34.0%和81.8%。结论 2型糖尿病患者下肢局部氧分压测定对于早期诊断糖尿病周围神经病变有一定的临床价值。

Correlation between transcutaneous oxygen pressure of lower extremity and peripheral neuropathy in type 2 diabetes patients

Objective To investigate the relationship between the level of transcutaneous oxygen pressure(TcPO2)in dorsalis pedis and the occurrence of peripheral neuropathy in patients with type 2 diabetes.Methods According to the EMG results,115 cases of type 2 diabetic were divided into two groups:66 patients with peripheral neuropathy(DPN)and 49 cases without neuropathy(NDPN).In addition,40 normal participants were served as the control group(Con).The TcPO2 in dorsalis pedis was detected in all subjects by TCM-400,and the monitoring results and the abnormality rates were compared between groups.Results The TcPO2 level of Type 2 diabetes patients with peripheral neuropathy group was significantly lower than that of the non-peripheral neuropathy group of Type 2 diabetes patients(P < 0.05)and the control group(P <0.05).The abnormal rate of TcPO2 in the group of normal participants,type 2 diabetes patients without peripheral neuropathy,type 2 diabetes patients with peripheral neuropathy was 12.5%,34.0%,and 81.8% respectively.Conclusion Transcutaneous oxygen pressure test for the lower limbs of patients with type 2 diabetes in the early diagnosis of diabetic peripheral neuropathy has certain clinical value.