缺氧与肿瘤化疗耐药关系研究

缺氧是晚期实体肿瘤特征性的微环境。缺氧与肿瘤的恶性进展,包括肿瘤细胞的增殖、分化、凋亡、表型的决定、血管生成、能量代谢、对治疗的抵抗）以及病人的预后密切相关。本文总结了近年来临床和实验室对肿瘤缺氧研究的相关报道,重点对肿瘤缺氧与肿瘤耐药的相关性进行归纳,为缺氧和肿瘤耐药研究做一理论铺垫,并为耐药性肿瘤的治疗提供思路。

Relation of Hypoxia and drug resistance of tumor

Hypoxia is characteristic property of locally advanced solid tumors. Hypoxia is associated with development of tumor （including proliferation, differentiation, apoptosis, aggressive phenotype, angio- genesis, metabolism and resistance to treatment） and patients＇ prognosis. The goal of this review is to com- pile current results from experimental and clinical studies, illuslrate the interaction between hypoxia and resistance towarl oncologic treatment, so as to provide basis for further study and open the door to therapy of resistance tumor.