卡培他滨单药节拍化治疗老年晚期胃癌21 例疗效观察

目的探讨卡培他滨小剂量、高频率、持续性给药治疗老年晚期胃癌的疗效。方法将42例临床IV期胃癌患者分为对照组和观察组：对照组采用XELOX化疗方案,观察组采用卡培他滨节拍化疗方案。两组均给予2个周期的化疗和对症支持治疗用药：维生素C,维生素B6,地塞米松、西米替丁、阿扎司琼、胃复安、粒细胞集落刺激因子等。结果对照组CR为9.52%,PR为57.41%,SD为19.05%,PD为14.29%,RR为66.67%,止痛药减少者57.89%,疼痛减轻者42.11%,KPS改善者61.90%,体重增加者28.57%,不良反应发生率为204.76%;观察组CR为14.29%,PR为52.38%,SD为23.81%,PD为9.52%,RR为66.67%,止痛药减少者85.0%,疼痛减轻者15.0%,KPS改善者76.19%,体重增加者42.86%,不良反应发生率为133.33%。结论卡培他滨单药节拍化治疗用于老年晚期胃癌患者,不良反应少,疗效和临床受益与XELOX化疗方案用药无差异。

The efficacy of Capecitabine in metronomic treatment for elderly advanced gastric cancer in 21 cases

Objective To investigate the efficacy of capecitabine with low dose,high frequency and continuous infusion in treatment of elderly advanced gastric cancer.Method Forty patients with stage IV gastric cancer patients were divided into control group and observation group：control group were received XELOX chemotherapy regimen,and the observation group were received capecitabine metronomic chemotherapy.Both groups were given two courses chemotherapies,symptomatic and supportive therapeutic drugs：vitamin C,vitamin B6,dexamethasone,cimetidine,Azasetron,metoclopramide,granulocyte colonystimulating factor et al.Results In control group,CR was 9.52%,PR 57.41%,SD 19.05%,PD 14.29%,RR 66.67%,less painkillers 57.89%,and pain relief were 42.11%,KPS improved 61.90%,weight increased 28.57%,incidence of adverse reactions 204.76%;and in the observation group CR 14.29%,PR 52.38%,SD 23.81%,PD 9.52%,RR 66.67%,less pain medication 85.0%,and pain relief were 15.0%,KPS improved 76.19%,weight increased 42.86%,incidence of adverse reactions was 133.33%.Conclusion Capecitabine metronomic chemotherapy in the treatment for elderly patients with advanced gastric cancer can make less adverse reactions and similar efficacy and clinical benefit to the XELOX regimen.