| IMMUNOCYTOCHEMICAL CHARACTERIZATION OF CD44 MOLECULES EXPRESSED IN HUMAN BRAIN METASTASES |
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| 引用本文： | 李宏,刘佳.IMMUNOCYTOCHEMICAL CHARACTERIZATION OF CD44 MOLECULES EXPRESSED IN HUMAN BRAIN METASTASES[J].中国癌症研究,1996,8(2):79-84. |
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| 作者姓名： | 李宏 刘佳 |
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| 作者单位： | Li Hong; Liu Jia; Martin Hofmann; Mariae-France Hasmou Nicolas de Tnbolet (Division of Molecular Bioiogr. Shenyang，Medical College，Sheenyang 110031) (Institute of Genetics (IGKN). D-76021 Karlsruhe. Germany)(Department of Neurosurgery，University H |
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| 摘 要： | ＩＭＭＵＮＯＣＹＴＯＣＨＥＭＩＣＡＬＣＨＡＲＡＣＴＥＲＩＺＡＴＩＯＮＯＦＣＤ４４ＭＯＬＥＣＵＬＥＳＥＸＰＲＥＳＳＥＤＩＮＨＵＭＡＮＢＲＡＩＮＭＥＴＡＳＴＡＳＥＳＬｉＨｏｎｇ李宏；ＬｉｕＪｉａ刘佳；ＭａｒｔｉｎＨｏｆｍａｎｎ；Ｍａｒｉａｅ－Ｆｒａｎｃｅ...
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| 修稿时间： | 9 February 1996 |
Immunocytochemical characterization of Cd44 molecules expressed in human brain metastases |
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| Li Hong,Liu Jia,Martin Hofmann,Mariae-France Hamou,Nicolas de Tribolet.Immunocytochemical characterization of Cd44 molecules expressed in human brain metastases[J].Chinese Journal of Cancer Research,1996,8(2):79-84. |
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| Authors: | Li Hong Liu Jia Martin Hofmann Mariae-France Hamou Nicolas de Tribolet |
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| Institution: | (1) Division of Molecular Biology, Shenyang Medical College, 110031 Shenyang;(2) Institute of Genetics (IGEN), D-76021 Karlsruhe, Germany;(3) Department of Neurosurgery, University Hospital (CHUV), 1011 Lausanne, Switzerland |
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| Abstract: | On the basis of analyses of differential CD44 expression Patterns between primary brain tumours and brain metastases and the high incidence of CD44v detection in brain metastases formed by various types of systemic tumours, wc further characterised CD44v proteins expressed in brain metastases studied previously with the antibodies specific for variant CD44v isoforms. The results demonstrate that CD44v expression in brain metastases is extremely heterogeneous. Generally, vs/v6 is homogeneously expressed in the cell populations, while up-regulated v7/vs or v7-v10 could be usually found in part of tumor cells, especially the ones close to necrosis, at tumour borders and with strong tendency of invasiveness. v7/v10 could also be detected in microvascular endothelial cells of the tumoours. Our data thus describe multispectrum CD44v expression in the same tumours and even in individual tumour cells and suggest the necessity to use more than one antibodies in the study of tD44 expression in human malignancies. |
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| Keywords: | CD44 Immunocytochemistry Metastasis |
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