止渴养阴胶囊联合门冬胰岛素治疗2型糖尿病的临床研究

目的研究止渴养阴胶囊联合门冬胰岛素治疗2型糖尿病的临床疗效和安全性。方法选取2013年2月—2015年10月于延安市人民医院就诊的2型糖尿病患者86例,随机分成对照组和治疗组,每组各43例。对照组皮下注射门冬胰岛素注射液,起始剂量0.6 U/kg,每隔1~2天根据空腹血糖(FPG)和餐后2 h血糖(2 h PG)水平调整剂量。治疗组在对照组的基础上口服止渴养阴胶囊,3粒/次,3次/d。两组患者均连续治疗3个月。观察两组的临床疗效,同时比较两组治疗前后的FPG、2 h PG、Hb Alc、空腹C肽、2 h C肽水平、血糖达标时间、日血糖波动情况、日胰岛素用量以及低血糖发生率。结果治疗后,对照组和治疗组的总有效率分别为81.40%、95.35%,两组比较差异有统计学意义(P0.05)。治疗后FPG、2 h PG、Hb Alc水平下降,空腹C肽水平升高,同组治疗前后差异具有统计学意义(P0.05);且治疗组FPG、2 h PG、Hb Alc和空腹C肽水平改善程度优于对照组,差异具有统计学意义(P0.05)。治疗后治疗组血糖达标时间明显缩短,日胰岛素用量减少,低血糖发生率降低,两组比较差异有统计学意义(P0.05)。结论止渴养阴胶囊联合门冬胰岛素能够显著的提高2型糖尿病的治疗效果,减少日胰岛素用量少,降低低血糖发生率。

Clinical study of Zhike Yangyin Capsules combined with insulin aspart in treatment of type 2 diabetes

Objective To study the clinical efficacies and safety of Zhike Yangyin Capsules combined with insulin aspart in treatment of type 2 diabetes. Methods Patients (86 cases) with type 2 diabetes in Yan''an People''s Hospital from February 2013 to October 2015 were randomly divided into control group and treatment group, and each group had 43 cases. The patients in the control group were sc administered with Insulin Aspart Injection, the initial dosage was 0.6 U/kg, and the dosage was adjusted every 1-2 d according to FPG and 2 h PG levels. The patients in the treatment group were po administered with Zhike Yangyin Capsules on the basis of the control group, 3 grains/time, three times daily. The patients in two groups were treated for 3 months. After treatment, clinical efficacies were evaluated. And FPG, 2 h PG, HbAlc, fasting C-peptide, 2 h C-peptide, reaching target of glucose time, daily blood glucose fluctuation, daily insulin dosage, and hypoglycemia incidence in two groups before and after treatment were compared. Results After treatment, the clinical efficacies in the control and treatment groups were 81.40% and 95.35%, respectively, and there were significant differences between two groups (P<0.05). After treatment, FPG, 2 h PG, and HbAlc levels in two groups were obviously decreased, and fasting C-peptide was obviously increased, the difference was statistically significant in the same group (P<0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P<0.05). After treatment, reaching target of glucose time in the treatment group was significantly shortened, daily insulin dosage was reduced, and hypoglycemia incidence was decreased, with significant difference between two groups (P<0.05). Conclusion Zhike Yangyin Capsules combined with insulin aspart has a good clinical curative effect in treatment of type 2 diabetes, which can reduce daily insulin dosage and the incidence of hypoglycemia.