| 1H-MRS评价新生儿缺氧缺血性脑病 |
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| 引用本文： | 王瑞珠,杨明,席艳丽,朱明水. 1H-MRS评价新生儿缺氧缺血性脑病[J]. 中国医学影像技术, 2016, 32(8): 1175-1178 |
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| 作者姓名： | 王瑞珠 杨明 席艳丽 朱明水 |
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| 作者单位： | 南京医科大学附属南京儿童医院放射科, 江苏 南京 210008,南京医科大学附属南京儿童医院放射科, 江苏 南京 210008,南京医科大学附属南京儿童医院放射科, 江苏 南京 210008,南京医科大学附属南京儿童医院放射科, 江苏 南京 210008 |
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| 基金项目： | 南京市科技发展项目基金（YKK14117）。 |
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| 摘 要： | 目的 探讨1H-MRS评价新生儿缺氧缺血性脑病（HIE）的价值。方法 收集经临床确诊的足月HIE患儿30例（HIE组）和无神经系统异常新生儿16例（对照组）。于出生后22天内行头颅1H-MRS扫描，分别计算胆碱/肌酸（Cho/Cr）、N-乙酰天门冬氨酸/肌酸（NAA/Cr）、N-乙酰天门冬氨酸/胆碱（NAA/Cho）、乳酸/肌酸（Lac/Cr）比值，并进行统计学分析。结果 与对照组比较，HIE组Lac/Cr升高（P<0.05），NAA/Cr，NAA/Cho均降低（P均<0.05），Cho/Cr差异无统计学意义（P>0.05）。多因素Logistic回归分析结果示NAA/Cr、Lac/Cr是HIE的独立危险因素（P均<0.05）。结论 1H-MRS可客观反映HIE患儿缺氧缺血后代谢变化，更好地评价脑损伤的严重程度，有助于HIE的早期诊断及治疗。
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| 关 键 词： | 婴儿,新生 缺氧缺血性脑病 磁共振波谱 磁共振成像 |
| 收稿时间： | 2015-12-23 |
| 修稿时间： | 2016-05-20 |
1H-MRS in evaluation of hypoxic-ischemic encephalopathy on neonates |
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| WANG Ruizhu,YANG Ming,XI Yanli and ZHU Mingshui. 1H-MRS in evaluation of hypoxic-ischemic encephalopathy on neonates[J]. Chinese Journal of Medical Imaging Technology, 2016, 32(8): 1175-1178 |
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| Authors: | WANG Ruizhu YANG Ming XI Yanli ZHU Mingshui |
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| Affiliation: | Department of Radiology, Nanjing Children''s Hospital Affliated to Nanjing Medical University, Nanjing 210008, China,Department of Radiology, Nanjing Children''s Hospital Affliated to Nanjing Medical University, Nanjing 210008, China,Department of Radiology, Nanjing Children''s Hospital Affliated to Nanjing Medical University, Nanjing 210008, China and Department of Radiology, Nanjing Children''s Hospital Affliated to Nanjing Medical University, Nanjing 210008, China |
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| Abstract: | Objective To explore the value of 1H-MRS in evaluation of hypoxic-ischemic encephalopathy (HIE) in neonates. Methods Totally 30 full-term neonates with HIE confirmed by clinic (HIE group) and 16 infants without nervous system abnormalities (control group) were collected. Cerebral 1H-MRS was performed within 22 days after birth. Choline/creatine (Cho/Cr), N-acetylaspartate/creatine (NAA/Cr), N-acetylaspartate/choline (NAA/Cho), lactic acid/creatine (Lac/Cr) were canculated respectively, and statistical analysis was carried out. Resluts Compared to control group, Lac/Cr in HIE group was statistically increased (P<0.05), and NAA/Cr, NAA/Cho were both statistically decreased (both P<0.05). The difference of Cho/Cr between 2 groups had no statistical significance (P>0.05). Logistic regression analysis showed NAA/Cr and Lac/Cr were independent risk factors of HIE (both P<0.05). Conclusion 1H-MRS can objectively reflect brain metabolic changes of HIE, and it is a usful method to evaluate brain injury. |
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| Keywords: | Infant, newborn Hypoxic-ischemic encephalopathy Magnetic resonance spectroscopy Magnetic resonance imaging |
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