枫蓼肠胃康片联合奥美拉唑和复方嗜酸乳杆菌治疗急性胃肠炎的临床研究

目的观察枫蓼肠胃康片联合奥美拉唑和复方嗜酸乳杆菌治疗急性胃肠炎的临床疗效。方法选取2015年2月—2016年2月在建始县中医院接受治疗的急性胃肠炎患者94例,随机分为对照组和治疗组,每组各47例。两组患者均给予急性胃肠炎的对症治疗。对照组口服奥美拉唑肠溶片,20 mg/次,1次/d;同时口服复方嗜酸乳杆菌片,1 g/次,3次/d。治疗组在对照组的基础上口服枫蓼肠胃康片,4片/次,3次/d。两组患者均连续治疗2周。观察两组的临床疗效,同时比较治疗前后两组的临床症状评分,以及血清降钙素(PCT)、白细胞介素-6(IL-6)和IL-8的水平变化。结果治疗后,对照组的总有效率为82.98%,治疗组为95.74%,两组总有效率比较差异具有统计学意义(P0.05)。两组的临床症状评分和总积分均较治疗前显著降低(P0.05),且与对照组相比,治疗组降低更为明显,两组比较差异具有统计学意义(P0.05)。两组PCT、IL-6、IL-8水平均较治疗前明显下降(P0.05),且治疗组的血清学指标水平较对照组下降的更为明显(P0.05)。结论枫蓼肠胃康片联合奥美拉唑和复方嗜酸乳杆菌治疗急性胃肠炎疗效显著,可明显改善患者临床症状,减轻机体炎症反应,具有一定的临床推广应用价值。

Clinical study on Fengliao Changweikang Tablets combined with omeprazole and compound eosinophil-lactobacillus in treatment of acute gastroenteritis

Objective To observe the clinical curative effect of Fengliao Changweikang Tablets combined with omeprazole and compound eosinophil-lactobacillus in treatment of acute gastroenteritis. Methods Patients (94 cases) with acute gastroenteritis in Jianshi Hospital of TCM from February 2015 to February 2016 were randomly divided into control and treatment groups. Each group had 47 cases. All patients were given symptomatic treatment of acute gastroenteritis. Patients in the control group were po administrated with Omeprazole Enteric-coated Tablets, 20 mg/time, once daily. And they were po administered with Compound Eosinophil-Lactobacillus Tablets, 1 g/d, three times daily. On the basis of control group, patients in the treatment group were po administrated with Fengliao Changweikang Tablets, 4 tablets/time, three times daily. Two groups were treated for 2 weeks. After treatment, the efficacy was evaluated, clinical symptom scores and levels of serum PCT, IL-6, and IL-8 between two groups were compared. Results After treatment, clinical efficacy in the treatment groups was 95.74% which was significantly higher than that (82.98%) of the control group, and the difference was statistically significant between two groups (P<0.05). After treatment, clinical symptom scores and total integral in two groups were obviously decreased (P<0.05). These observational indexes in the treatment group were better than those in the control group, with significant difference between two groups (P<0.05). After treatment, levels of PCT, IL-6 and IL-8 in two groups were significantly decreased (P<0.05), and the decreasing degree of these serological indexes in the treatment group were more obviously than that in the control group (P<0.05). Conclusion Fengliao Changweikang Tablets combined with omeprazole and compound eosinophil-lactobacillus has a good clinical curative effect in treatment of acute gastroenteritis in treatment of acute gastroenteritis, can significantly improve the clinical symptoms, and relieve inflammatory reaction, which has a certain clinical application value.