| 鬼臼毒素聚合物胶团对人胶质瘤细胞的抑制作用 |
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| 引用本文： | 王耿焕,沈和平,金成胜,黄嬛,蒋小红,褚正民,王翊飞. 鬼臼毒素聚合物胶团对人胶质瘤细胞的抑制作用[J]. 中国现代应用药学, 2016, 33(10): 1248-1251 |
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| 作者姓名： | 王耿焕 沈和平 金成胜 黄嬛 蒋小红 褚正民 王翊飞 |
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| 作者单位： | 嘉兴学院附属第二医院, 浙江 嘉兴 314000,嘉兴学院附属第二医院, 浙江 嘉兴 314000,嘉兴学院附属第二医院, 浙江 嘉兴 314000,浙江嘉兴学院医学院, 浙江 嘉兴 314001,浙江嘉兴学院医学院, 浙江 嘉兴 314001,嘉兴学院附属第二医院, 浙江 嘉兴 314000,嘉兴学院附属第二医院, 浙江 嘉兴 314000 |
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| 基金项目： | 浙江省自然科学基金项目（Y2081030）；浙江省医药卫生科技计划（2013KYA199） |
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| 摘 要： | 目的 合成鬼臼毒素聚合物胶团，评价其对人胶质瘤细胞的增殖抑制作用。方法 制备鬼臼毒素聚合物胶团，考察其理化性质，通过肿瘤细胞摄取实验，噻唑蓝（MTT）法检测其对U87细胞的增殖抑制作用。结果 鬼臼毒素聚合物胶团比游离药物鬼臼毒素对人胶质瘤细胞有更大的增殖抑制作用，显著增加肿瘤细胞内的药物浓度。结论 鬼臼毒素聚合物胶团对人脑胶质瘤细胞增殖有明显的抑制作用。
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| 关 键 词： | 鬼臼毒素 聚合物胶团 抗肿瘤活性 人胶质瘤细胞 |
| 收稿时间： | 2016-01-22 |
Antitumor Activity of Stearic Acid Grafted Chitosan Oligosaccharide Polymeric Micelles Loading Podophyllotoxin Against Human Glioma Cells |
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| WANG Genghuan,SHEN Heping,JIN Chengsheng,HUANG Xuan,JIANG Xiaohong,CHU Zhengmin and WANG Yifei. Antitumor Activity of Stearic Acid Grafted Chitosan Oligosaccharide Polymeric Micelles Loading Podophyllotoxin Against Human Glioma Cells[J]. The Chinese Journal of Modern Applied Pharmacy, 2016, 33(10): 1248-1251 |
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| Authors: | WANG Genghuan SHEN Heping JIN Chengsheng HUANG Xuan JIANG Xiaohong CHU Zhengmin WANG Yifei |
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| Affiliation: | The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China,The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China,The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China,Medical College of Jiaxing University, Jiaxing 314001, China,Medical College of Jiaxing University, Jiaxing 314001, China,The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China and The Second Affiliated Hospital of Jiaxing University, Jiaxing 314000, China |
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| Abstract: | OBJECTIVE To investigate the effect of stearic acid grafted chitosan oligosaccharide polymeric micelles loading podophyllotoxin(CSO-SA/PPT) on the cell proliferation in human glioma cells. METHODS CSO-SA/PPT were prepared to investigate its physical and chemical properties. U87 cell proliferative activity was measured by tumor cell uptake assay and MTT assay. RESULTS The CSO-SA/PPT had greater inhibition on human glioma cells proliferation compared with free podophyllotoxin formulation. And in vitro drug uptake tests showed that CSO-SA/PPT presented more uptake characteristics than free podophyllotoxin. CONCLUSION CSO-SA/PPT plays an inhibitory role in the cell proliferation in human glioma cells. |
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| Keywords: | podophyllotoxin polymeric micelle antitumour activity human glioma cells |
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