康妇炎胶囊联合苦参碱栓治疗阴道炎的临床研究

目的探讨康妇炎胶囊联合苦参碱栓治疗阴道炎的临床疗效。方法收集海南省临高县人民医院2015年2月—2016年2月收治的阴道炎患者84例,按照治疗方法的不同分成对照组和治疗组,每组各42例。对照组使用苦参碱栓,1次/d。治疗组在对照组的基础上口服康妇炎胶囊,3粒/次,2次/d。两组患者均连续治疗14 d。观察两组的临床疗效,同时比较治疗前后两组的白带减少、外阴瘙痒消失、外阴阴道疼痛消失和黏膜充血消失的时间,以及白细胞介素-2(IL-2)、IL-8和IL-13水平的变化情况。结果治疗后,治疗组的总有效率(95.24%)明显高于对照组(80.95%),两组总有效率比较差异有统计学意义(P0.05);治疗组治疗后的白带减少、外阴瘙痒消失、外阴阴道疼痛消失和黏膜充血消失的时间均比对照组短,两组比较差异具有统计学意义(P0.05)。两组患者阴道灌洗液中IL-2、IL-8和IL-13水平显著降低,同组治疗前后差异具有统计学意义(P0.05);治疗组治疗后的上述炎性因子降低更明显,与对照组治疗后的比较差异具有统计学意义(P0.05)。结论康妇炎胶囊联合苦参碱栓治疗阴道炎效果显著,可明显改善患者临床症状和减轻炎症反应。

Clinical study on Kangfuyan Capsules combined with Matrine Suppositories in treatment of vaginitis

Objective To explore the clinical efficacies of Kangfuyan Capsules combined with Matrine Suppositories in treatment of vaginitis. Methods Patients (84 cases) with vaginitis in Lingao People''s Hospital from February 2015 to February 2016were divided into control and treatment groups according to the different treatment methods, and each group had 42 cases. Patients in the control group were given Matrine Suppositories, once daily. Patients in the treatment group were po administered with Kangfuyan Capsules on the basis of control group, 3 grains/time, twice daily. The patients in two groups were treated for 14 d. After treatment, the efficacy was evaluated, the leucorrhea reduced time and the disappearance time of pruritus vulvae, vulva vaginal pains and mucosa engorgement, and the changes of IL-2, IL-8, and IL-13 were compared. Results After treatment, the clinical efficacy of patients in treatment group (95.24%) were higher than that in control group (80.95%) with significant difference (P<0.05). The leucorrhea reduced time and the disappearance time of pruritus vulvae, vulva vaginal pains and mucosa engorgement were shorter than those in control group, and the difference was statistically significant between two groups (P<0.05). IL-2, IL-8 and IL-13 levels in vaginal lavage of two groups were significantly reduced, and the difference was statistically significant in the same group (P<0.05). After treatment, IL-2, IL-8 and IL-13 levels in the treatment group were better than those in control group with significant difference between two groups (P<0.05). Conclusion Kangfuyan Capsules combined with Matrine Suppositories in treatment of vaginitis has a significant clinical efficacy, can significantly improve the clinical symptoms and reduce the inflammatory reaction.