子宫肌瘤患者术前醋酸亮丙瑞林预处理的疗效观察

摘 要 目的：观察子宫肌瘤患者术前采用醋酸亮丙瑞林预处理的疗效。方法: 70例子宫肌瘤患者随机分为观察组和对照组，每组35例。对照组行腹腔镜下子宫肌瘤剔除术。观察组先给予醋酸亮丙瑞林3.75 mg皮下注射，每月1次，连续治疗3个月后，再进行腹腔镜下子宫肌瘤剔除术。比较观察组患者使用醋酸亮丙瑞林前后的血清激素水平、月经情况、肌瘤及子宫体积变化，比较两组患者的术中术后情况、子宫肌瘤复发率。 结果: 观察组患者给予醋酸亮丙瑞林后，黄体生成素（LH）、卵泡刺激素（FSH）、血清雌二醇（E₂）水平均明显低于用药前（P<0.05），月经量、子宫体积、肌瘤体积明显小于用药前（P<0.05）。观察组患者的术中出血量、盆腔引流量明显低于对照组（P<0.05），下床活动时间、住院时间明显短于对照组（P<0.05）。结论:子宫肌瘤患者术前给予醋酸亮丙瑞林预处理，可明显降低患者的血清激素水平，缩小肌瘤体积，有利于开展子宫肌瘤剔除术，术中创伤较小，有利于患者的预后。

Effect of Leuprolide Preoperative Used in Patients with Uterine Fibroids

ABSTRACT Objective: To study the effect of leuprolide preoperative used in the patients with uterine fibroids. Methods: Totally 70 patients with uterine fibroids were divided into the observation group and the control group with 35 ones in each. The 35 patients in the control group were with laparoscopic myomectomy, and those in the observation group was given leuprolide, 3.75 mg per time, once in a month for 3 months, and then undergone laparoscopic myomectomy. The serum hormone levels, menstruation situation and fibroids and uterus volume changes in the observation group were observed and compared before the treatment and after the 3 month leuprolide treatment. The situation during the operation and after the operation, and the recurrence rate of uterine fibroids between the two groups were compared.Results:After the pretreatment of leuprolide, the levels of luteinizing hormone (LH), follicle stimulating hormone (FSH) and serum estradiol (E2) in the observation group were significantly lower than those before the treatment (P<0.05), and the menstrual blood volume, uterine volume and fibroid volume were significantly lower than those before the treatment, and the differences were statistically significant (P<0.05). The blood loss during the operation and pelvic drainage of the observation group were significantly lower than those of the control group, and the ambulation time and length of hospital stay of the observation group were significantly shorter than those of the control group with statistically significant differences (P<0.05). Conclusion:Leuprolide preoperative used in the patients with uterine fibroids can significantly reduce serum hormone levels and fibroid volume, which are beneficial to myomectomy with smaller surgery invasion and better prognosis.