利培酮合并帕罗西汀治疗强迫症疗效分析

目的：探讨利培酮合并帕罗西汀治疗强迫症的疗效。方法：40例强迫症患者随机分为利培酮合并帕罗西汀组和帕罗西汀组，治疗8周。采用强迫症量表(Y-BOCS)、汉密尔顿焦虑量表(HAMA)、汉密尔顿抑郁量表(HAMD)评定疗效。结果：治疗结束时两组Y-BOCs、HAMA、HAMD的评分均显著降低，更以合用利培酮组明显。结论：利培酮合并帕罗西汀治疗强迫症可以增加疗效。

Comparative analysis of risperidone combining with paroxetine in treatment of obsessive-compulsive disorder

Objective:To investigate the efficacy of risperidone combining with paroxetine in the treatment of obsessive-compulsive disorder(OCD). Method:40 patients with OCD were randomly treated with risperidone combining with paroxetine(n=20) and paroxetine only(n=20).The efficacy was measured with Yale-Brown obsessive compulsive scale (Y-BOCS),Hamilton anxiety scale (HAMA) and Hamilton depression scale (HAMD). Results:There were significant differences between two groups in overall response showed by the reduction rate of Y-BOCS,HAMA and HAMD total scores. Conclusion:It is suggested that risperidone combining with paroxetine have a superior effectiveness in the treatment of OCD.