大肠癌术后腹腔引流液中CEA、CA125和CA19-9的水平及其临床意义

目的 探讨大肠癌术后腹腔引流液中癌胚抗原（CEA）、糖类抗原125（CA125）和糖类抗原19-9（CA19-9）的水平及其与临床分期和腹腔微转移的关系。方法 收集经手术治疗的86例大肠癌患者（大肠癌组）和30例肠道良性疾病患者（对照组）术后第1天的腹腔引流液，检测腹腔引流液中CEA、CA125和CA19-9的水平，并分析其与大肠癌临床病理特征的关系。结果 大肠癌组腹腔引流液的CEA水平高于对照组（P＜0.05），CA125和CA19-9水平两组差异均无统计学意义（P＞0.05）；腹腔引流液中CA125和CA19 9水平与大肠癌临床病理特征无关（P＞0.05），而CEA水平与淋巴结转移、浸润深度和临床分期有关。结论 大肠癌术后腹腔引流液CEA检测可用于预测临床分期、腹腔微转移并判断预后。

Levels of CEA, CA125 and CA19-9 in postoperative peritoneal fluid drainage of colorectal cancer and their clinical significance

Objective To investigate the levels of carcinoembryonic antigen （CEA）, carbohydrate antigen （CA）125 and CA19-9 in postoperative peritoneal fluid drainage of colorectal cancer（CRC） and their relationship with clinical staging and peritoneal micrometastasis. Methods The peritoneal fluid drainage on postoperative day 1 was collected from 86 patients with CRC（ CRC group） and 30 patients with benign intestinal disease（control group）. The levels of CEA, CA125 and CA19-9 in postoperative peritoneal fluid drainage of CRC were detected and their relationship with clinicopathological features were analyzed. Results The level of CEA was higher in CRC group than that in the control group（P 〈0.05）, while there was no significant difference in CA125, CA19-9 between both groups （ P 〉 0.05）. There was significant correlation between the state of lymph node metastasis, depth of invasion and clinical stage with the level of CEA, while no relationship was found between the levels of CA125, CA19-9 and clinicopathological features. Conclusion The level of CEA in postoperative peritoneal fluid drainage of CRC can be used to predict clinical staging, peritoneal mi- crometastasis and prognosis.