| 氯吡格雷与质子泵抑制剂相互作用的争议及评价 |
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| 引用本文： | 李亮. 氯吡格雷与质子泵抑制剂相互作用的争议及评价[J]. 心血管病学进展, 2011, 32(3): 389-391. DOI: 10.3969/j.issn.1004-3934.2011.03.026 |
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| 作者姓名： | 李亮 |
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| 作者单位： | 南华大学,湖南衡阳,421001 |
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| 摘 要： | 目前共识建议指出对接受双联抗血小板治疗的患者给予质子泵抑制剂以降低胃肠道出血风险。但最近有研究表明,联用氯吡格雷质子泵抑制剂患者不良心血管事件高于单独使用氯吡格雷治疗者。现就质子泵抑制剂和氯吡格雷相互作用的争议和临床研究进展作一综述。
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| 关 键 词： | 质子泵抑制剂 氯吡格雷 药物相互作用 心血管事件 |
Controversies and Assessments of Interaction between Clopidogrel and Proton Pump Inhibitor |
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| LI Liang. Controversies and Assessments of Interaction between Clopidogrel and Proton Pump Inhibitor[J]. Advances in Cardiovascular Diseases, 2011, 32(3): 389-391. DOI: 10.3969/j.issn.1004-3934.2011.03.026 |
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| Authors: | LI Liang |
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| Affiliation: | LI Liang1,DENG Ping2(1.University of South China,Hengyang 421001,Hunan,China,2.Changsha Central Hospital,Changsha 410004,China) |
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| Abstract: | Current consensus recommendations that patients prescribed clopidogrel plus aspirin should receive a proton pump inhibitor(PPI) to reduce gastrointestinal bleeding.However,recent studies have shown higher rates of adverse cardiovascular events in patients on PPI and clopidogrel,in comparison to patients on clopidogrel only.This article reviews the controversies and advances in clinical research on the interaction between clopidogrel and PPI. |
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| Keywords: | proton pump inhibitor clopidogrel drug interactions cardiovascular adverse events |
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