乙肝患者不同时间点初次注射干扰素的不良反应及护理满意度比较

目的 比较乙肝患者不同时间点初次注射干扰素的不良反应发生情况及患者满意度.方法 选择90例患者,分为观察组和对照组,各45例,其中观察组晚上20：00进行初次注射,对照组择上午8：00左右进行注射,比较两组患者的发热相关持续时间及发热时显著不适症状和护理满意度.结果 观察组患者发热持续时间为（5.2±1.1）h,峰值体温为（37.9±0.2）℃;对照组分别为（7.9±1.4）h,（38.4±0.4）℃,两组比较差异有统计学意义（t值分别为7.389,5.276;P ＜0.05）;观察组患者头痛头晕、肌肉酸痛和呼吸困难发生率均低于对照组,护理满意度高于对照组,差异均有统计学意义（P＜0.01）.结论 晚上20：00初次注射干扰素能有效减轻患者的发热症状,缓解临床不适,有效提高护理满意度.

Comparison of adverse reaction and nursing satisfaction in patients with chronic hepatitis B at different time points of first injection of interferon

Objective To observe adverse reaction and nursing satisfaction in patients with chronic hepatitis B at different time points of first injection of interferon.Methods Ninety patients were chosen and randomly divided into the observation group and the control group,each with 45 cases.The observation group received the first injection at 8：00 pm,and the control group received the first injection at 8：00 am The time duration of fever,the fever associated with significant discomfort symptoms and nursing satisfaction were compared in two groups.Results The time duration of fever was （5.2 ± 1.1） h in the observation group,and was （7.9 ± 1.4） h in the control group,and the difference was statistically significant （t =7.389,P 〈 0.05）.The peak temperature was （37.9 ± 0.2） ℃ in the observation group,and was （38.4 ± 0.4） ℃ in the control group,and the difference was statistically significant （t =5.276,P 〈 0.05）.The incidence rates of headache and dizziness,muscle pain and dyspnea in the observation group were lower than those in the control group,and the nursing satisfaction in the observation group was higher than that in the control group,and the differences were statistically significant （P 〈 0.05）.Conclusions The first injection of interferon at 8：00 pm can effectively relieve the symptoms of fever,alleviate the fever associated with discomfort symptoms,and improve the nursing satisfaction.