Treatment of hepatitis B virus-associated membranous glomerulonephritis with interferon alfa in a 7 year old boy |
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Authors: | Steiss J O Piske-Keyser K Gröne H J Gortner L |
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Institution: | Zentrum für Kinderheilkunde, Justus-Liebig-Universit?t Giessen. |
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Abstract: | BACKGROUND: The association between Hepatitis B virus infection and membranous nephropathy has been confirmed by sources in several countries. Most commonly, the illness is seen as a nephrotic syndrome. Optimal treatment remains undefined. Antiviral therapies observed with recombinant human interferon alpha may be the best treatment option. CASE REPORT: We present a 7-year old boy with membranous glomerulonephritis and nephrotic syndrome. Twelve months after the initial hospitalization therapy was started with recombinant alpha-interferon s.c. three times weekly for six months. After the therapy the patient is stable, without proteinuria, edema or renal failure. He was seronegative for HBsAg, HBV-DNA and antibody to HBeAg. CONCLUSIONS: This case report suggests that alpha interferon is effective in the complete resolution of proteinuria in HBV membranous nephropathy. |
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