| 缺血性中风病中医证候要素动态变化与NIHSS评分变化相关性的贝叶斯网络分析 |
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| 引用本文： | 江丽杰 胡镜清,易丹辉 陈 倩 刘保延.缺血性中风病中医证候要素动态变化与NIHSS评分变化相关性的贝叶斯网络分析[J].世界中医药,2013,8(6):613-617. |
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| 作者姓名： | 江丽杰 胡镜清 易丹辉 陈 倩 刘保延 |
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| 作者单位： | 江丽杰 (中国中医科学院中医临床基础医学研究所,北京,100700)； 胡镜清 (中国中医科学院广安门医院中医临床研究方法重点研究室,北京,100053;河南中医学院,郑州,450008)； 易丹辉 (中国人民大学统计学院,北京,100872)； 陈倩 (中国人民大学统计学院,北京,100872)； 刘保延(中国中医科学院,北京,100700)； |
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| 基金项目： | 国家自然科学基金课题(项目编号：30873460),构建表征证候动态变化纵向结局评价指标的示范研究(项目编号：201107006)中医药行业科研专项课题中医慢病临床科研体系及其成果转化应用模式研究 |
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| 摘 要： | 目的：探讨缺血性中风病中医证候要素动态变化与NIHSS评分变化之间的关系。方法：以379例缺血性中风病临床数据为基础,在5个不同时点（0d、3d、14d、28d、3m）采集《中风病辨证诊断标准》中风、火、痰、瘀、气虚、阴虚阳亢6个证候要素的评分和《美国国立卫生院卒中量表》（NIHSS）评分,运用贝叶斯网络分析其相关性。结果：0～3d时,NIHSS评分改善,证候要素痰、瘀、阴虚阳亢和气虚的改善概率分别为0.809、0.896、0.934、0.961;3～14d时,火热、瘀、痰、阴虚阳亢和气虚的改善概率分别为0.546、0.843、0.895、0.962、0.944;14～28d时,火热、痰、阴虚阳亢和气虚的改善概率分别为0.53、0.815、0.966、0.987;28d至3m时,风、火热、瘀、痰、阴虚阳亢和气虚的改善概率分别为0.507、0.667、0.854、0.505、0.905、0.914,与NIHSS呈现出明显的正向关系。结论：缺血性中风病的NIHSS评分变化在不同时点均有多个证候要素评分与之相关,其相关程度随时间动态演变。
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| 关 键 词： | 缺血性中风病 证候 结局评价 贝叶斯网络 美国国立卫生院卒中量表 |
| 收稿时间： | 2013/5/23 0:00:00 |
Bayesian Network Analysis of Correlation between TCM Syndrome Dynamic Changes and NIHSS Scores of Ischemia Stroke |
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| Jianglijie,Hu Jingqing,Yi Danhui,Chen Qian,Liu Baoyan.Bayesian Network Analysis of Correlation between TCM Syndrome Dynamic Changes and NIHSS Scores of Ischemia Stroke[J].World Chinese Medicine,2013,8(6):613-617. |
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| Authors: | Jianglijie Hu Jingqing Yi Danhui Chen Qian Liu Baoyan |
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| Institution: | 1 Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences,Beijing 100700,China;2 TCM Clinical Research Laboratory,Guang’anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;3 Henan College of Chinese Medicine,Zhengzhou 450008,China;4 School of Statistics,Renmin University of China,Beijing 100872,China;5 China Academy of Chinese Medical Sciences,Beijing 100700,China) |
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| Abstract: | Objective：To investigate the correlation between TCM syndrome dynamic changes and NIHSS scores of ischemia stroke.Methods：The patients with ischemia stroke（n = 379） were selected and their scores of six syndrome factors（wind,fire,phlegm,stasis,qi-deficiency and hyperactivity of yang due to yin-deficiency） according to the Diagnostic Standard of Syndrome Differentiation of Stroke and the National Institutes of Health Stroke Scale（NIHSS） at 5 different time points（0d,3d,14d,28d,3m） were recorded respectively.The correlation between syndrome factors and NIHSS scores at different time points were studied by using the method of Bayesian network.Results：NIHSS were improved during 0d-3d,and the improvement rate of phlegm,stasis,hyperactivity of yang due to yin-deficiency and qi-deficiency were respectively 0.809,0.896,0.934,0.961;during 3d-14d,the improvement rate of fire,stasis,phlegm,hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.546,0.843,0.895,0.962,0.944;during 14d-28d,the improvement rate of fire,phlegm,hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.53,0.815,0.966,0.987;during 28d-3m,the improvement rate of wind,fire,stasis,phlegm,hyperactivity of yang due to yin-deficiency and qi-deficiency were 0.507,0.667,0.854,0.505,0.905,0.914.Conclusion：There is a correlation between TCM syndrome factors manifestations and NIHSS scores in ischemia stroke at different time points,and the correlation degree changes dynamically over time. |
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| Keywords: | Ischemia stroke TCM syndrome Outcome evaluation Bayesian network NIHSS |
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