Storage of platelet concentrates harvested from blood collected into dextrose-free preservative without agitation |
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Authors: | A Farrugia S Douglas K Karabagias S Gutowski A Ram |
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Institution: | Product Development Unit, Victoria Red Cross Blood Bank, cnr Balston &Kavanagh Streets, South Melbourne, Victoria, Australia 3205 |
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Abstract: | Summary. This study addresses the possibility of platelet quality being maintained during storage by an endogenous metabolic fuel, while avoiding dextrose-induced lactate accumulation. This was achieved by harvesting platelet concentrates from blood donations collected into a dextrose-free anticoagulant. Adequate maintenance of all metabolic and functional parameters was observed in platelets from blood collected into 4% citrate. The requirement for platelets stored in CPD plasma to be agitated during storage was confirmed, but agitation could be omitted for dextrose-free platelets without increased lactate generation and a drop in pH. These results indicate that platelet concentrates from dextrose-free blood may be stored without some of the constraints accompanying platelet storage in conventional media, and may thus result in improved delivery of this product. |
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Keywords: | platelet concentrates agitation storage dextrose |
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