动态增强MRI定量参数在乳腺癌患者中的应用及与乳腺癌分子亚型间的关系

目的探讨动态增强MRI定量参数在乳腺癌患者中的应用及与乳腺癌分子亚型间的关系。方法取2013年11月~2016年12月在我院收治的乳腺癌患者78例作为研究对象,术前利用MRI进行定量参数K~(trans)、K_(ep)和Ve水平测定。利用免疫组织化学法完成ER、PR、HER-2水平检测。结果 68例乳腺癌患者中,Luminal A型23例、Luminal B型20例、HER-2+型12例和TNBC型13例。Luminal A型K_(ep)水平,高于Luminal B型、HER-2+型及TNBC型(P0.05);Luminal B型K_(ep)水平,高于HER-2+型及TNBC型(P0.05);ER阳性Kep,低于阴性(P0.05);PR阳性K~(trans)、K_(ep),低于阴性(P0.05)。结论利用动态增强MRI能准确的鉴别乳腺癌不同分型,不同分型下乳腺癌中ER、PR表达水平不同。

Application of dynamic enhanced MRI quantitative parameters in breast cancer patients and its eelationship with molecular subtypes of breast cancer

Objective To investigate the application of dynamic enhanced MRI quantitative parameters in breast cancer patients and its relationship with molecular subtypes of breast cancer.Methods A total of 78 patients with breast cancer who were admitted to our hospital from November 2013 to December 2016 were selected as the subjects.Quantitative parameters of Ktrans,Kepand Ve levels were measured by MRI before surgery,and ER,PR and HER-2 levels were determined by immunohistochemistry.Results Of the 68 patients with breast cancer,23 were in type Luminal A,20 in type Luminal B,12 in type HER-2+and 13 in type TNBC.Keplevel in Luminal A was higher than that in Luminal B, HER-2+and TNBC(P<0.05);Keplevel in Luminal B was higher than that in HER-2+and TNBC(P<0.05);Kepin ER-positive was lower than that in ER-negative(P<0.05);levels of Ktransand Kepin PR-positive were lower than those in PR-negative(P<0.05).Conclusion The application of dynamic contrast-enhanced MRI can accurately identify different subtypes of breast cancer,and the expression levels of ER and PR is different in different subtypes of breast cancer.