多重耐药鲍曼不动杆菌药敏情况分析

目的分析多重耐药鲍曼不动杆菌的临床分离和药敏情况,并与普通鲍曼不动杆菌的情况进行比较。方法回顾性分析49株多重耐药鲍曼不动杆菌和498株普通鲍曼不动杆菌的耐药情况,采用χ2检验分析两类细菌对常用抗菌药物的敏感性差异。结果药敏实验证实产鲍曼不动杆菌多重耐药株和普通株除对阿米卡星、多粘菌素B、氯霉素、氨曲南和头孢唑啉的敏感性差异无统计学意义外(P0.05),对其他抗菌药物如亚南培南、环丙沙星等的敏感性都存在显著性差异(P0.05),多重耐药鲍曼不动杆菌对很多抗菌药物的耐药率相比普通株都有很大程度的提高。结论多重耐药鲍曼不动杆菌存在耐药机制的多样性情况,在临床确诊鲍曼不动杆菌多重耐药株感染时应根据药敏结果合理用药,同时应珍惜使用对多重耐药鲍曼不动杆菌和普通鲍曼不动杆菌治疗同样有效的多粘菌素B及阿米卡星等抗菌药物。

Drug sensitivity analysis of multidrug-resistant Acinetobacter baumannii

Objective To analyze the clinical isolation and drug susceptibility of multidrug-resistant Acinetobacter baumannii and to compare with that of Acinetobacter baumannii.Methods The drug resistance of 49 multidrug-resistant Acinetobacter baumannii and 498 ordinary Acinetobacter baumannii was retrospectively analyzed.The differences of the sensitivity of the two kinds of bacteria to commonly used antimicrobial agents were analyzed by Chi-square test.Results The results of drug susceptibility test showed that there was no significant difference in the sensitivity to amikacin,polymyxin B,chloramphenicol,aztreonam and cefazolin between the multidrug-resistant strains of Acinetobacter baumannii and the common strains(P>0.05).There was significant difference in the sensitivity to other antibacterial drugs such as imipenem and ciprofloxacin(P<0.05).The drug resistance rate of multidrug-resistant Acinetobacter baumannii to many antibacterials have greatly improved,compared to that of ordinary strains.Conclusion There are a diversity of drug resistance mechanisms for multidrug-resistant Acinetobacter baumannii.When the infection of Acinetobacter baumannii multi-drug-resistant strains is clinically diagnosed,the drug should be used rationally according to the susceptibility results.At the same time,the antibiotics such as polymyxin B and amikacin,which have the same effect on multidrug-resistant strains and the common strains of Acinetobacter baumannii,shoud be used carefully.